Safety Profile
Overall safety rating: Caution Needed
Fadogia Agrestis Side Effects & Safety
Evidence:Preliminary
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Potential Side Effects
- SIGNIFICANT CONCERN: testicular histological changes (damage to seminiferous tubules) observed in rats at 100 mg/kg — long-term safety in humans is completely unknown
- Elevated liver and kidney function markers observed in animal studies at higher doses
- No human safety data exists — all side effect information is extrapolated from rat studies
- Anecdotal reports from users include elevated heart rate, insomnia, and mood changes
Drug & Supplement Interactions
- Testosterone replacement therapy — potential additive effects; avoid combining without medical supervision
- Fertility medications — unknown interaction potential due to lack of human data
- Hepatotoxic medications — animal data suggests potential liver effects; use caution with other hepatotoxic substances
Maximum Dose
Do not exceed: No established safe upper limit in humans; animal studies showed toxicity at higher doses (100 mg/kg in rats)