Skip to main content
SupplementScience

Fadogia Agrestis Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Caution Needed

Potential Side Effects

  • SIGNIFICANT CONCERN: testicular histological changes (damage to seminiferous tubules) observed in rats at 100 mg/kg — long-term safety in humans is completely unknown
  • Elevated liver and kidney function markers observed in animal studies at higher doses
  • No human safety data exists — all side effect information is extrapolated from rat studies
  • Anecdotal reports from users include elevated heart rate, insomnia, and mood changes

Drug & Supplement Interactions

  • Testosterone replacement therapy — potential additive effects; avoid combining without medical supervision
  • Fertility medications — unknown interaction potential due to lack of human data
  • Hepatotoxic medications — animal data suggests potential liver effects; use caution with other hepatotoxic substances

Maximum Dose

Do not exceed: No established safe upper limit in humans; animal studies showed toxicity at higher doses (100 mg/kg in rats)

Full Fadogia Agrestis Guide

References

  1. (). Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats. Asian Journal of Andrology. DOI
  2. (). Androgenic potentials of aqueous extract of Fadogia agrestis stem in male Wistar rats. Asian Journal of Andrology. DOI