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Fisetin — Frequently Asked Questions

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Frequently Asked Questions

What are senescent cells and why clear them?

Senescent cells are damaged cells that stop dividing but refuse to die. They accumulate with age and secrete inflammatory molecules (the SASP) that damage surrounding healthy tissue, drive chronic inflammation, and accelerate aging. Clearing these "zombie" cells with senolytics like fisetin has been shown to improve health and extend lifespan in animal models.

Should I take fisetin daily or intermittently?

Both approaches are used. Daily low doses (100-500mg) provide ongoing antioxidant and anti-inflammatory benefits. Intermittent high-dose protocols (1-2g for 2 consecutive days monthly) mimic the senolytic protocols used in clinical trials. The optimal approach for humans is still being determined in ongoing Mayo Clinic trials.

Can I get enough fisetin from strawberries?

Strawberries are the richest food source, containing about 160μg fisetin per gram. To reach a 500mg supplemental dose, you would need to eat approximately 3kg (6.6 lbs) of strawberries daily, which is impractical. Supplementation is necessary for therapeutic doses.

Full Fisetin Guide

References

  1. (). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine. DOI
  2. (). Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimer's disease transgenic mice. Aging Cell. DOI
  3. (). New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463. Aging. DOI