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| Form | Bioavailability | Best For |
|---|---|---|
| Folic Acid (Synthetic) | High | Standard supplementation and food fortification — most studied form; requires DHFR enzyme conversion |
| L-Methylfolate (5-MTHF) | Very High | MTHFR variants and active folate needs — directly bioactive, bypasses conversion; preferred for those with MTHFR C677T or A1298C polymorphisms |
| Folinic Acid (5-Formyl-THF) | High | Medical use — bypass of dihydrofolate reductase, used in methotrexate rescue protocols |
Bioavailability: High. Best for: Standard supplementation and food fortification — most studied form; requires DHFR enzyme conversion.
Bioavailability: Very High. Best for: MTHFR variants and active folate needs — directly bioactive, bypasses conversion; preferred for those with MTHFR C677T or A1298C polymorphisms.
Bioavailability: High. Best for: Medical use — bypass of dihydrofolate reductase, used in methotrexate rescue protocols.
