Safety Profile
Overall safety rating: Generally Safe
Garlic Extract (Aged / Allicin) Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Garlic breath and body odor (less with AGE)
- GI discomfort (heartburn, nausea, bloating)
- Increased bleeding risk at high doses
- Allergic reactions (rare — contact dermatitis, asthma)
Drug & Supplement Interactions
- Anticoagulants/antiplatelets (warfarin, aspirin) — may increase bleeding risk
- HIV protease inhibitors (saquinavir) — garlic may reduce drug levels by inducing CYP3A4
- Isoniazid — garlic may reduce absorption
- Hypotensive medications — additive blood pressure-lowering effects
Maximum Dose
Do not exceed: 2400mg AGE/day (well-tolerated in clinical trials)
References
- Ried K (2016). Garlic Lowers Blood Pressure in Hypertensive Individuals, Regulates Serum Cholesterol, and Stimulates Immunity: An Updated Meta-analysis and Review. Journal of Nutrition. DOI PubMed
- Matsumoto S, Nakanishi R, Li D, Alani A, Rezaeian P, Budoff MJ (2016). Aged Garlic Extract Reduces Low Attenuation Plaque in Coronary Arteries of Patients with Metabolic Syndrome. Journal of Nutrition. DOI PubMed
- Sobenin IA, Andrianova IV, Demidova ON, Gorchakova T, Orekhov AN (2008). Lipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized study. Journal of Atherosclerosis and Thrombosis. DOI PubMed