Evidence Level
Strong
Ginger has one of the strongest evidence bases among herbal supplements for GI applications. Anti-nausea evidence is robust across pregnancy (Cochrane review), chemotherapy (large multicenter RCT), and post-surgical settings. Prokinetic effects are well-documented in human studies. The mechanism involves 5-HT3 receptor antagonism (similar to ondansetron), enhanced antral contractions, and anti-inflammatory gingerols. It is safe in pregnancy — no evidence of teratogenicity or adverse pregnancy outcomes in systematic reviews.