General Dosage
500-1000mg liposomal glutathione daily or 600-1800mg NAC daily
Maximum dose: 2000mg/day oral glutathione or 2400mg/day NAC
Glutathione (Liver Support) Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 500-1000mg liposomal glutathione daily or 600-1800mg NAC daily
Timing: Take on an empty stomach for best absorption (liposomal form); NAC can be taken with or without food
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| General liver antioxidant support | 500mg liposomal GSH or 600mg NAC daily | Moderate |
| NAFLD/fatty liver | 500-1000mg liposomal GSH or 1200-1800mg NAC daily | Moderate |
| Chemical/drug exposure support | 1000mg liposomal GSH or 1200mg NAC daily | Strong |
| Acetaminophen overdose (clinical) | IV NAC per clinical protocol (hospital setting only) | Strong |
Upper limit: 2000mg/day oral glutathione or 2400mg/day NAC
Timing & Absorption
Take on an empty stomach for best absorption (liposomal form); NAC can be taken with or without food
Can be taken with or without food.
References
- Hayes JD, Flanagan JU, Jowsey IR (2005). Glutathione transferases. Annual Review of Pharmacology and Toxicology. DOI PubMed
- Prescott LF, Park J, Ballantyne A, Adriaenssens P, Proudfoot AT (1979). Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet. DOI PubMed
- Honda Y, Kessoku T, Sumida Y, Kobayashi T, Kato T, Ogawa Y, Tomeno W, Imajo K, Fujita K, Yoneda M, Kataoka K, Taguri M, Yamanaka T, Seko Y, Tanaka S, Saito S, Ono M, Oeda S, Eguchi Y, Aoi W, Sato K, Itoh Y, Nakajima A (2017). Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. BMC Gastroenterology. DOI PubMed
- Lu SC (2013). Glutathione synthesis. Biochimica et Biophysica Acta. DOI PubMed