Skip to main content
Supplement ScienceSupplementScience

Glutathione (Liver Support) Dosage Guide

Evidence:Strong
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

500-1000mg liposomal glutathione daily or 600-1800mg NAC daily

Maximum dose: 2000mg/day oral glutathione or 2400mg/day NAC

Dosage Recommendations

General recommendation: 500-1000mg liposomal glutathione daily or 600-1800mg NAC daily

Timing: Take on an empty stomach for best absorption (liposomal form); NAC can be taken with or without food

Dosage by Condition

General liver antioxidant support
500mg liposomal GSH or 600mg NAC dailyModerate
NAFLD/fatty liver
500-1000mg liposomal GSH or 1200-1800mg NAC dailyModerate
Chemical/drug exposure support
1000mg liposomal GSH or 1200mg NAC dailyStrong
Acetaminophen overdose (clinical)
IV NAC per clinical protocol (hospital setting only)Strong

Upper limit: 2000mg/day oral glutathione or 2400mg/day NAC

Timing & Absorption

Take on an empty stomach for best absorption (liposomal form); NAC can be taken with or without food

Can be taken with or without food.

Full Glutathione (Liver Support) Guide

References

  1. ReviewHayes JD, Flanagan JU, Jowsey IR (2005). Glutathione transferases. Annual Review of Pharmacology and Toxicology. DOI PubMed
  2. Prescott LF, Park J, Ballantyne A, Adriaenssens P, Proudfoot AT (1979). Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet. DOI PubMed
  3. ObservationalHonda Y, Kessoku T, Sumida Y, Kobayashi T, Kato T, Ogawa Y, Tomeno W, Imajo K, Fujita K, Yoneda M, Kataoka K, Taguri M, Yamanaka T, Seko Y, Tanaka S, Saito S, Ono M, Oeda S, Eguchi Y, Aoi W, Sato K, Itoh Y, Nakajima A (2017). Efficacy of glutathione for the treatment of nonalcoholic fatty liver disease: an open-label, single-arm, multicenter, pilot study. BMC Gastroenterology. DOI PubMed
  4. ReviewLu SC (2013). Glutathione synthesis. Biochimica et Biophysica Acta. DOI PubMed
  5. Meta-analysisMohideen K, Jeddy N, Krithika C, Faizee SH, et al. (2023). Assessment of glutathione peroxidase enzyme response and total antioxidant status in oral cancer - Systematic review and meta-analysis.. Cancer reports (Hoboken, N.J.). DOI PubMed
  6. Meta-analysisLee N, Park SM, Yee J, Yoon HY, et al. (2020). Association Between Glutathione-S-Transferase Gene Polymorphisms and Responses to Tyrosine Kinase Inhibitor Treatment in Patients with Chronic Myeloid Leukemia: A Meta-analysis.. Targeted oncology. DOI PubMed
  7. Meta-analysisZhang M, Wu SQ, He JQ (2019). Are genetic variations in glutathione S-transferases involved in anti-tuberculosis drug-induced liver injury? A meta-analysis.. Journal of clinical pharmacy and therapeutics. DOI PubMed
Show 4 more references
  1. Meta-analysisLiu WZ, Sun Y, Feng X, Bi XH, et al. (2018). An updated meta-analysis for association of glutathione S-transferase P1 gene polymorphism with the susceptibility of lung cancer.. Journal of cancer research and therapeutics. DOI PubMed
  2. Meta-analysisHuang M, Zeng Y, Zhao F, Huang Y (2018). Association of glutathione S-transferase M1 polymorphisms in the colorectal cancer risk: A meta-analysis.. Journal of cancer research and therapeutics. DOI PubMed
  3. Meta-analysisZhou T, Li HY, Xie WJ, Zhong Z, et al. (2018). Association of Glutathione S-transferase gene polymorphism with bladder Cancer susceptibility.. BMC cancer. DOI PubMed
  4. Meta-analysisWang H, Gao X, Zhang X, Gong W, et al. (2018). Glutathione S-Transferase Gene Polymorphisms are Associated with an Improved Treatment Response to Cisplatin-Based Chemotherapy in Patients with Non-Small Cell Lung Cancer (NSCLC): A Meta-Analysis.. Medical science monitor : international medical journal of experimental and clinical research. DOI PubMed