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Holy Basil (Tulsi) Side Effects & Safety

Evidence:Moderate
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Generally well-tolerated at recommended doses
  • Mild nausea in some individuals
  • May lower blood sugar — monitor if diabetic
  • May have mild anti-fertility effects (high-dose animal studies)

Drug & Supplement Interactions

  • May enhance effects of blood sugar-lowering medications
  • May have additive effects with anticoagulant/antiplatelet drugs (eugenol inhibits platelet aggregation)
  • May slow blood clotting — discontinue 2 weeks before surgery
  • Avoid during pregnancy due to potential uterotonic effects

Maximum Dose

Do not exceed: 1200mg extract daily (higher doses not well-studied long-term)

Full Holy Basil (Tulsi) Guide

References

  1. ReviewJamshidi N, Cohen MM (2017). The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature. Evidence-Based Complementary and Alternative Medicine. DOI PubMed
  2. RCTSaxena RC, Singh R, Kumar P, et al. (2012). Efficacy of an Extract of Ocimum tenuiflorum (OciBest) in the Management of General Stress. Journal of Ayurveda and Integrative Medicine. DOI PubMed