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| Form | Bioavailability | Best For |
|---|---|---|
| Low-Molecular-Weight HA (< 300 kDa) | Moderate | Oral supplementation — smaller molecules are better absorbed in the gut |
| High-Molecular-Weight HA (> 1,000 kDa) | Low (oral) | Topical application — forms a hydrating film on the skin surface |
| Sodium Hyaluronate | Moderate | Common supplement form — the sodium salt of HA with good stability and solubility |
| Acetylated HA | Moderate-High | Enhanced skin penetration — acetyl group improves lipophilicity for topical use |
Bioavailability: Moderate. Best for: Oral supplementation — smaller molecules are better absorbed in the gut.
Bioavailability: Low (oral). Best for: Topical application — forms a hydrating film on the skin surface.
Bioavailability: Moderate. Best for: Common supplement form — the sodium salt of HA with good stability and solubility.
Bioavailability: Moderate-High. Best for: Enhanced skin penetration — acetyl group improves lipophilicity for topical use.
