Safety Profile
Overall safety rating: Generally Safe
Hyaluronic Acid Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Very well tolerated — adverse event rates similar to placebo in clinical trials
- Rare mild GI discomfort
- Theoretical concern in individuals with active cancer (HA receptors involved in cell proliferation) — no clinical evidence of risk
Drug & Supplement Interactions
- No significant drug interactions reported for oral HA supplementation
- Safe to combine with glucosamine, chondroitin, and other joint supplements
Maximum Dose
Do not exceed: Up to 240mg daily has been studied safely; no established upper limit
References
- Tashiro T, Seino S, Sato T, et al. (2012). Oral administration of polymer hyaluronic acid alleviates symptoms of knee osteoarthritis: a double-blind, placebo-controlled study over a 12-month period. The Scientific World Journal. DOI PubMed
- Nelson FR, Zvirbulis RA, Engelman DS, et al. (2015). The effects of an oral preparation containing hyaluronic acid on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. Rheumatology International. DOI PubMed
- Oe M, Tashiro T, Yoshida H, et al. (2016). Oral hyaluronan relieves knee pain: a review. Nutrition Journal. DOI PubMed