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Iodine (Thyroid) Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Safe with Caution

Potential Side Effects

  • Metallic taste in mouth
  • Nausea and stomach upset at higher doses
  • Excess iodine can trigger or worsen hypothyroidism or hyperthyroidism (Wolff-Chaikoff effect or Jod-Basedow phenomenon)
  • Acne-like skin eruptions (iododerma) at high doses

Drug & Supplement Interactions

  • May interfere with levothyroxine and other thyroid medications — monitor TSH
  • Lithium combined with iodine increases hypothyroidism risk
  • ACE inhibitors and potassium-sparing diuretics combined with potassium iodide may cause hyperkalemia

Maximum Dose

Do not exceed: 1,100mcg (1.1mg) daily Tolerable Upper Intake Level for adults (IOM)

References

  1. (). Iodine deficiency. Endocrine Reviews. DOI
  2. (). Iodine-deficiency disorders. The Lancet. DOI