General Dosage
5-10 g daily, taken in divided doses or post-workout
Maximum dose: 40 g/day has been used in clinical settings; 20 g/day is a typical upper dose for supplements
L-Glutamine Dosage Guide
Evidence:Moderate
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Dosage Recommendations
General recommendation: 5-10 g daily, taken in divided doses or post-workout
Timing: Can be taken any time; post-workout or divided throughout the day
Dosage by Condition
Gut barrier support
5-10 g daily in divided dosesModerate
Exercise recovery
5-10 g post-workoutEmerging
Immune support
10-20 g daily during illness/stressModerate
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Gut barrier support | 5-10 g daily in divided doses | Moderate |
| Exercise recovery | 5-10 g post-workout | Emerging |
| Immune support | 10-20 g daily during illness/stress | Moderate |
Upper limit: 40 g/day has been used in clinical settings; 20 g/day is a typical upper dose for supplements
Timing & Absorption
Can be taken any time; post-workout or divided throughout the day
Can be taken with or without food.
References
- ReviewCieri-Hutcherson NE, Hutcherson TC, Conway-Habes EE, Burns BN, et al. (2019). Systematic Review of l-glutamine for Prevention of Vaso-occlusive Pain Crisis in Patients with Sickle Cell Disease.. Pharmacotherapy. DOI PubMed
- RCTHassanein FEA, Mikhail C, Elkot S, Abou-Bakr A (2025). L-arginine vs. L-glutamine oral suspensions for radiation-induced oral mucositis: a triple-blind randomized trial.. Journal of cancer research and clinical oncology. DOI PubMed
- RCTLu TL, Zheng AC, Suzuki K, Lu CC, et al. (2024). Supplementation of L-glutamine enhanced mucosal immunity and improved hormonal status of combat-sport athletes.. Journal of the International Society of Sports Nutrition. DOI PubMed
- Bloomer RJ, Pence J, Hellenbrand J, Davis A, et al. (2024). Randomized Trial to Assess the Safety and Tolerability of Daily Intake of an Allulose Amino Acid-Based Hydration Beverage in Men and Women.. Nutrients. DOI PubMed
- RCTTsujimoto T, Wasa M, Inohara H, Ito T (2023). L-Glutamine and Survival of Patients with Locally Advanced Head and Neck Cancer Receiving Chemoradiotherapy.. Nutrients. DOI PubMed
- ObservationalPavel FM, Bungau SG, Tit DM, Ghitea TC, et al. (2023). Clinical Implications of Dietary Probiotic Supplement (Associated with L-Glutamine and Biotin) in Ulcerative Colitis Patients' Body Composition and Quality of Life.. Nutrients. DOI PubMed
- Adiamah A, Skorepa P, Weimann A, Lobo DN (2024). Effects of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine supplementation on outcomes.. Journal of parenteral and enteral nutrition. DOI PubMed
Show 2 more references
- Weimann A, Braga M, et al. (2024). Impact of preoperative beta-hydroxy-beta-methylbutyrate, arginine, and glutamine on outcomes.. Clinical nutrition ESPEN. DOI PubMed
- Tepaske R, et al. (2022). Evaluation of the recovery after heart surgery following preoperative supplementation with glutamine, arginine, and omega-3 fatty acids.. Nutrition. DOI PubMed