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L-Glutathione Research & Evidence

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Evidence Level

Moderate

Glutathione is the body's principal antioxidant, but oral supplementation was long considered ineffective due to GI degradation. A 2015 RCT by Richie et al. (n=54) demonstrated that oral GSH at 250-1000 mg/day for 6 months increased blood glutathione levels by 30-35%. Liposomal and S-acetyl forms further improve bioavailability. NAC remains a cost-effective alternative that boosts endogenous GSH production.

Evidence by Condition

ConditionStudied DoseEvidence
General antioxidant support250-500 mg daily (liposomal)Moderate
Liver and detox support500-1000 mg dailyModerate
Skin brightening500 mg daily for 4+ weeksModerate
Immune support500-1000 mg dailyModerate
Full L-Glutathione Guide

References

  1. (). Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. European Journal of Nutrition. DOI
  2. (). Glutathione and its antiaging and antimelanogenic effects. Clinical, Cosmetic and Investigational Dermatology. DOI
  3. (). Glutathione: overview of its protective roles, measurement, and biosynthesis. Molecular Aspects of Medicine. DOI