Skip to main content
Supplement ScienceSupplementScience

Types of Magnolia Bark: Forms & Bioavailability

Evidence:Emerging
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Forms Comparison

FormBioavailabilityBest For
Relora (Magnolia + Phellodendron Extract)ModerateStress and cortisol — the most clinically studied standardized preparation
Standardized Magnolia Bark Extract (2% honokiol)ModerateSleep and anxiety — focused on the primary anxiolytic compound honokiol
High-Honokiol Extract (90%+ honokiol)HighTargeted GABA modulation — concentrated honokiol for potent anxiolytic and sleep effects

Relora (Magnolia + Phellodendron Extract)

Bioavailability: Moderate. Best for: Stress and cortisol — the most clinically studied standardized preparation.

Standardized Magnolia Bark Extract (2% honokiol)

Bioavailability: Moderate. Best for: Sleep and anxiety — focused on the primary anxiolytic compound honokiol.

High-Honokiol Extract (90%+ honokiol)

Bioavailability: High. Best for: Targeted GABA modulation — concentrated honokiol for potent anxiolytic and sleep effects.

Full Magnolia Bark Guide

References

  1. RCTTalbott SM, Talbott JA, Pugh M (2013). Effect of Magnolia officinalis and Phellodendron amurense (Relora) on cortisol and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition. DOI PubMed
  2. In-vitroAlexeev M, Grosenbaugh DK, Bhatt MH, et al. (2012). The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptors. Neuropharmacology. DOI PubMed
  3. ReviewThomas AJ, Ismail R, Taylor-Swanson L, Cray L, et al. (2014). Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the menopausal transition and early postmenopause: a systematic review.. Maturitas. DOI PubMed
  4. RCTAgosta C, Atlante M, Benvenuti C (2011). Randomized controlled study on clinical efficacy of isoflavones plus Lactobacillus sporogenes, associated or not with a natural anxiolytic agent in menopause.. Minerva ginecologica. PubMed