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SupplementScience

MCT Oil Side Effects & Safety

Reviewed by·PharmD, BCPS

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • GI distress (nausea, cramping, diarrhea) — very common when starting too fast; dose-dependent
  • Loose stools at higher doses, especially with C8-dominant products
  • Mild nausea when taken on a completely empty stomach
  • Rarely: elevated LDL cholesterol in some individuals with prolonged high-dose use

Drug & Supplement Interactions

  • May alter blood glucose and ketone levels — use caution with diabetes medications
  • High caloric density (115 kcal per tablespoon) may affect weight if not accounted for in total intake
  • No significant drug-drug interactions have been identified in clinical trials

Maximum Dose

Do not exceed: 45ml (3 tablespoons) daily — GI distress is common above this level

Full MCT Oil Guide

References

  1. Mumme K, Stonehouse W (2015). Effects of medium-chain triglycerides on weight loss and body composition: a meta-analysis of randomized controlled trials. Journal of the Academy of Nutrition and Dietetics. DOI PubMed
  2. Reger MA, Henderson ST, Hale C, et al. (2004). Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiology of Aging. DOI PubMed
  3. St-Onge MP, Bosarge A (2008). Weight-loss diet that includes consumption of medium-chain triacylglycerol oil leads to a greater rate of weight and fat mass loss than does olive oil. American Journal of Clinical Nutrition. DOI PubMed
  4. Ota M, Matsuo J, Ishida I, et al. (2019). Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer's disease. Neuroscience Letters. DOI PubMed
  5. Clegg ME (2010). Medium-chain triglycerides are advantageous in promoting weight loss although not beneficial to exercise performance. International Journal of Food Sciences and Nutrition. DOI PubMed
  6. Courchesne-Loyer A, Fortier M, Tremblay-Mercier J, et al. (2013). Stimulation of mild, sustained ketonemia by medium-chain triacylglycerols in healthy humans: estimated potential contribution to brain energy metabolism. Nutrition. DOI PubMed
  7. Vandenberghe C, St-Pierre V, Pierotti T, Fortier M, Castellano CA, Cunnane SC (2017). Tricaprylin Alone Increases Plasma Ketone Response More Than Coconut Oil or Other Medium-Chain Triglycerides. Current Developments in Nutrition. DOI PubMed