Pine Bark Extract (Pycnogenol) — Frequently Asked Questions

Pycnogenol enhances erectile function by stimulating endothelial nitric oxide synthase (eNOS), increasing nitric oxide production in blood vessels. Nitric oxide is the key molecule that relaxes penile smooth muscle and enables erections — this is the same pathway targeted by Viagra. When combined with L-arginine (the precursor to NO), Pycnogenol creates a synergistic effect. Clinical trials show the combination restored normal erectile function in over 90% of men with mild-to-moderate ED.

Pycnogenol (especially the Prelox combination with L-arginine) is not a direct replacement for PDE5 inhibitors like sildenafil (Viagra). Clinical trials show excellent results for mild-to-moderate ED, but the mechanism and potency differ. Pycnogenol works upstream by increasing NO production, while Viagra works downstream by preventing NO breakdown. Some men may benefit from Pycnogenol as a daily supplement for ongoing vascular health, with PDE5 inhibitors available for on-demand use. Consult your urologist.