General Dosage
10-50mg daily for general hormonal support
Maximum dose: 100mg daily without medical supervision; higher doses only in clinical settings
Pregnenolone Dosage Guide
Evidence:Preliminary
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Dosage Recommendations
General recommendation: 10-50mg daily for general hormonal support
Timing: Morning on an empty stomach or with a light meal
Dosage by Condition
Age-related hormone decline
10-30mg dailyPreliminary
Cognitive support
30-50mg dailyPreliminary
Mood support
50-100mg daily (under supervision)Preliminary
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Age-related hormone decline | 10-30mg daily | Preliminary |
| Cognitive support | 30-50mg daily | Preliminary |
| Mood support | 50-100mg daily (under supervision) | Preliminary |
Upper limit: 100mg daily without medical supervision; higher doses only in clinical settings
Timing & Absorption
Morning on an empty stomach or with a light meal
Can be taken with or without food.
References
- RCTMarx CE, Keefe RS, Buchanan RW, Hamer RM, Kilts JD, Bradford DW, Strauss JL, Naylor JC, Payne VM, Lieberman JA, Savitz AJ, Leimone LA, Dunn L, Porcu P, Morrow AL, Shampine LJ (2009). Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology. DOI PubMed
- RCTBrown ES, Park J, Marx CE, Hynan LS, Gardner C, Davila D, Nakamura A, Sunderajan P, Lo A, Holmes T (2014). A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology. DOI PubMed
- Meta-analysisLi H, Shen H, Duan X, Guo M, et al. (2026). Efficacy and safety of anti-inflammatory drug-assisted treatment of symptoms in patients with schizophrenia: a meta-analysis.. BMC psychiatry. DOI PubMed
- RCTStomati M, Monteleone P, Casarosa E, Quirici B, et al. (2000). Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause.. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. DOI PubMed