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Saccharomyces Boulardii Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Very well tolerated; mild gas in some individuals
  • Fungemia risk in immunocompromised patients or those with central venous catheters (rare but serious)
  • Should not be opened near central line patients — airborne yeast can colonize catheters

Drug & Supplement Interactions

  • Antifungals (fluconazole, nystatin) — will kill S. boulardii and negate probiotic benefit
  • Antibacterial antibiotics — no interaction (S. boulardii is a yeast and inherently resistant)
  • Immunosuppressants — use with caution; fungemia risk in severely immunocompromised

Maximum Dose

Do not exceed: 1,000mg (20 billion CFU) per day

Full Saccharomyces Boulardii Guide

References

  1. (). Systematic review with meta-analysis: Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea. Alimentary Pharmacology & Therapeutics. DOI
  2. (). Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World Journal of Gastroenterology. DOI