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Saffron (Macular Health) Side Effects & Safety

Evidence:Emerging
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Generally very well tolerated at recommended doses
  • Nausea and headache at very high doses (>200 mg)
  • Possible mood changes at extremely high intakes
  • Allergic reactions in individuals sensitive to Crocus species

Drug & Supplement Interactions

  • Anticoagulants — saffron may have mild antiplatelet properties at high doses
  • Antidepressant medications — saffron has serotonergic activity and may potentiate SSRIs
  • Blood pressure medications — saffron may have mild hypotensive effects

Maximum Dose

Do not exceed: 200 mg/day short-term has been tolerated; standard supplemental doses are 20-30 mg/day

Full Saffron (Macular Health) Guide

References

  1. RCTFalsini B, Piccardi M, Minnella A, et al. (2010). Influence of saffron supplementation on retinal flicker sensitivity in early age-related macular degeneration. Investigative Ophthalmology & Visual Science. DOI PubMed
  2. ObservationalPiccardi M, Marangoni D, Minnella AM, et al. (2012). A longitudinal follow-up study of saffron supplementation in early age-related macular degeneration. Evidence-Based Complementary and Alternative Medicine. DOI PubMed
  3. RCTMarangoni D, Falsini B, Piccardi M, et al. (2013). Functional effect of saffron supplementation and risk genotypes in early age-related macular degeneration. Nutrients. DOI PubMed