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Types of SAMe (S-Adenosyl Methionine): Forms & Bioavailability

Evidence:Strong
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Forms Comparison

FormBioavailabilityBest For
SAMe Tosylate DisulfateModerateMost common and best-studied supplement form — enteric coating required
SAMe ButanedisulfonateModeratePharmaceutical form used in European clinical trials — most stable salt form

SAMe Tosylate Disulfate

Bioavailability: Moderate. Best for: Most common and best-studied supplement form — enteric coating required.

SAMe Butanedisulfonate

Bioavailability: Moderate. Best for: Pharmaceutical form used in European clinical trials — most stable salt form.

Full SAMe (S-Adenosyl Methionine) Guide

References

  1. Meta-analysisSoeken KL, Lee WL, Bausell RB, et al. (2002). Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. Journal of Family Practice. PubMed
  2. RCTNajm WI, Reinsch S, Hoehler F, et al. (2004). S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. BMC Musculoskeletal Disorders. DOI PubMed
  3. RCTKim J, Lee EY, Koh EM, et al. (2009). Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis. Journal of Korean Medical Science. DOI PubMed
  4. ReviewHardy ML, Coulter I, Morton SC, et al. (2003). S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease. Evidence Report/Technology Assessment (AHRQ). PubMed