Serrapeptase — Frequently Asked Questions
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Frequently Asked Questions
What does SPU mean on serrapeptase labels?
What does SPU mean on serrapeptase labels?
SPU (Serratiopeptidase Units) measures the enzyme's proteolytic activity. A typical dose is 60,000-120,000 SPU (equivalent to 10-60mg). Some products use SU (Serrapeptase Units). Always compare enzymatic activity units, not just milligrams, when choosing products.
Why must serrapeptase be enteric-coated?
Why must serrapeptase be enteric-coated?
Serrapeptase is a protein enzyme that is destroyed by stomach acid. Enteric coating protects it until it reaches the alkaline environment of the small intestine, where it is absorbed intact into the bloodstream. Without enteric coating, most of the enzyme is inactivated before absorption.
How does serrapeptase compare to bromelain?
How does serrapeptase compare to bromelain?
Both are proteolytic enzymes used for inflammation. Serrapeptase has stronger fibrinolytic (clot-dissolving) activity, while bromelain has broader clinical evidence and COX-modulating effects. Some practitioners combine them. Bromelain has a larger evidence base, but serrapeptase may be superior for fibrin-related conditions.
References
- Al-Khateeb TH, Nusair Y (2008). Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. International Journal of Oral and Maxillofacial Surgery. DOI PubMed
- Mazzone A, Catalani M, Costanzo M, et al. (1990). Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology. Journal of International Medical Research. DOI PubMed
- Bhagat S, Agarwal M, Roy V (2013). Serratiopeptidase: a systematic review of the existing evidence. International Journal of Surgery. DOI PubMed