Skip to main content
SupplementScience

Serrapeptase Side Effects & Safety

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Gastrointestinal discomfort (nausea, diarrhea) — uncommon with enteric-coated forms
  • Skin reactions (dermatitis, itching) — rare
  • Potential increased bleeding risk due to fibrinolytic activity
  • Rare case reports of pneumonitis with long-term use

Drug & Supplement Interactions

  • Anticoagulants (warfarin, aspirin, heparin) — serrapeptase has fibrinolytic activity; may increase bleeding risk
  • Antibiotics — serrapeptase may increase tissue penetration of antibiotics (potentially beneficial interaction)
  • NSAIDs — additive anti-inflammatory effects; may allow dose reduction under supervision

Maximum Dose

Do not exceed: Up to 60mg daily has been used in clinical studies without significant adverse effects

Full Serrapeptase Guide

References

  1. (). Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. International Journal of Oral and Maxillofacial Surgery. DOI
  2. (). Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology. Journal of International Medical Research. DOI
  3. (). Serratiopeptidase: a systematic review of the existing evidence. International Journal of Surgery. DOI