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Serrapeptase Side Effects & Safety

Evidence:Emerging
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Gastrointestinal discomfort (nausea, diarrhea) — uncommon with enteric-coated forms
  • Skin reactions (dermatitis, itching) — rare
  • Potential increased bleeding risk due to fibrinolytic activity
  • Rare case reports of pneumonitis with long-term use

Drug & Supplement Interactions

  • Anticoagulants (warfarin, aspirin, heparin) — serrapeptase has fibrinolytic activity; may increase bleeding risk
  • Antibiotics — serrapeptase may increase tissue penetration of antibiotics (potentially beneficial interaction)
  • NSAIDs — additive anti-inflammatory effects; may allow dose reduction under supervision

Maximum Dose

Do not exceed: Up to 60mg daily has been used in clinical studies without significant adverse effects

Full Serrapeptase Guide

References

  1. RCTMazzone A, Catalani M, Costanzo M, et al. (1990). Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology. Journal of International Medical Research. DOI PubMed
  2. ReviewBhagat S, Agarwal M, Roy V (2013). Serratiopeptidase: a systematic review of the existing evidence. International Journal of Surgery. DOI PubMed