General Dosage
1-6mg daily from standardized wheat germ extract
Maximum dose: 6mg/day (doses above this have limited safety data)
Spermidine Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 1-6mg daily from standardized wheat germ extract
Timing: Morning with breakfast; consistent daily use is recommended for autophagy benefits • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| General longevity / autophagy support | 1-3mg daily | Emerging |
| Cognitive support | 1.2mg daily (from wheat germ) | Emerging |
| Cardiovascular health | 1-6mg daily | Emerging |
Upper limit: 6mg/day (doses above this have limited safety data)
Timing & Absorption
Morning with breakfast; consistent daily use is recommended for autophagy benefits
Best taken with food for optimal absorption.
References
- Eisenberg T, Abdellatif M, Schroeder S, et al. (2016). Cardioprotection and lifespan extension by the natural polyamine spermidine. Nature Medicine. DOI PubMed
- Madeo F, Eisenberg T, Pietrocola F, Kroemer G (2018). Spermidine in health and disease. Science. DOI PubMed
- Wirth M, Benson G, Schwarz C, et al. (2018). The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial. Cortex. DOI PubMed