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Stinging Nettle Root — Frequently Asked Questions

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Frequently Asked Questions

Does nettle root really increase free testosterone?

In vitro studies demonstrate that nettle root lignans bind SHBG and can displace testosterone from SHBG binding sites, which would theoretically increase free (bioavailable) testosterone. However, clinical studies measuring actual free testosterone changes from nettle root supplementation alone are limited. The SHBG-binding effect is well-documented in laboratory settings but clinical quantification in humans needs more research. Most clinical trials have focused on prostate symptom outcomes rather than hormone levels.

Is nettle root the same as nettle leaf?

No, they are different parts of the same plant with different uses. Nettle root (Urtica dioica radix) is used for prostate health, SHBG binding, and BPH symptoms. Nettle leaf (Urtica dioica folium) is used for allergies, inflammation, and joint pain, and contains different active compounds (including histamine and vitamin K). When shopping for men's health benefits, specifically look for "nettle root" extract, not "nettle leaf" or "stinging nettle" (which usually refers to the leaf).

Can I combine nettle root with saw palmetto?

Yes, this is one of the best-studied herbal combinations for prostate health. The PRO 160/120 formulation (saw palmetto 160mg + nettle root 120mg) has been studied in multiple RCTs and was found comparable to finasteride for BPH symptom relief with fewer side effects. Many European urologists recommend this combination as a first-line phytotherapy before considering pharmaceutical options.

Full Stinging Nettle Root Guide

References

  1. (). Urtica dioica for treatment of benign prostatic hyperplasia: a prospective, randomized, double-blind, placebo-controlled, crossover study. Journal of Herbal Pharmacotherapy. DOI
  2. (). Long-term efficacy and safety of a combination of sabal and urtica extract for lower urinary tract symptoms — a placebo-controlled, double-blind, multicenter trial. World Journal of Urology. DOI
  3. (). Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG). Planta Medica. DOI