General Dosage
400-600mg daily, divided into 2 doses
Maximum dose: 600mg/day (higher doses not well-studied)
Sulbutiamine Dosage Guide
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Dosage Recommendations
General recommendation: 400-600mg daily, divided into 2 doses
Timing: Morning and early afternoon with food; cycle 5 days on, 2 off to prevent tolerance • Take with food for best absorption.
Dosage by Condition
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Mental fatigue | 400-600mg daily | Emerging |
| Cognitive enhancement | 400mg daily | Emerging |
| Motivation and drive | 600mg daily | Preliminary |
Upper limit: 600mg/day (higher doses not well-studied)
Timing & Absorption
Morning and early afternoon with food; cycle 5 days on, 2 off to prevent tolerance
Best taken with food for optimal absorption.
References
- Micheau J, Durkin TP, Destrade C, et al. (1985). Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation. Pharmacology Biochemistry and Behavior. DOI PubMed
- Tiev KP, Cabane J, Imbert JC (1999). Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo. La Revue de Médecine Interne. DOI PubMed
- Dmitriev DG, Gamidov SI, Permiakova OV (2005). Clinical efficacy of the drug sulbutiamine in the treatment of erectile dysfunction in patients with psychogenic and mixed organic etiology. Urologiia. PubMed