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Sulbutiamine Dosage Guide

Evidence:Emerging
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

400-600mg daily, divided into 2 doses

Maximum dose: 600mg/day (higher doses not well-studied)

Dosage Recommendations

General recommendation: 400-600mg daily, divided into 2 doses

Timing: Morning and early afternoon with food; cycle 5 days on, 2 off to prevent tolerance • Take with food for best absorption.

Dosage by Condition

Mental fatigue
400-600mg dailyEmerging
Cognitive enhancement
400mg dailyEmerging
Motivation and drive
600mg dailyPreliminary

Upper limit: 600mg/day (higher doses not well-studied)

Timing & Absorption

Morning and early afternoon with food; cycle 5 days on, 2 off to prevent tolerance

Best taken with food for optimal absorption.

Full Sulbutiamine Guide

References

  1. RCTTiev KP, Cabane J, Imbert JC (1999). Treatment of chronic postinfectious fatigue: randomized double-blind study of two doses of sulbutiamine (400-600 mg/day) versus placebo. La Revue de Médecine Interne. DOI PubMed
  2. ReviewStarling-Soares B, Carrera-Bastos P, Bettendorff L (2020). Role of the Synthetic B1 Vitamin Sulbutiamine on Health.. Journal of nutrition and metabolism. DOI PubMed
  3. Micheau J, Durkin TP, Destrade C, et al. (1985). Chronic administration of sulbutiamine improves long term memory formation in mice: possible cholinergic mediation. Pharmacology Biochemistry and Behavior. DOI PubMed