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Urolithin A Dosage Guide

Evidence:Insufficient
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

250-500mg daily

Maximum dose: No established human upper tolerable limit; clinical trials have utilized up to 500mg daily

Dosage Recommendations

General recommendation: 250-500mg daily

Timing: Once daily, consistent timing recommended to maintain steady-state concentrations • Take with food for best absorption.

Dosage by Condition

Mitophagy induction and muscle function
250mg dailyModerate (Human RCTs)
Physical performance and endurance
500mg dailyEmerging (Small-scale human studies)

Upper limit: No established human upper tolerable limit; clinical trials have utilized up to 500mg daily

Timing & Absorption

Once daily, consistent timing recommended to maintain steady-state concentrations

Best taken with food for optimal absorption.

Full Urolithin A Guide

References

  1. D'Amico D, Andreux PA, Valdés P, Singh A, et al. (2021). Impact of the Natural Compound Urolithin A on Health, Disease, and Aging.. Trends in molecular medicine. DOI PubMed
  2. Liu S, D'Amico D, Shankland E, Bhayana S, et al. (2022). Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial.. JAMA network open. DOI PubMed
  3. DiNicolantonio JJ, McCarty MF, O'Keefe JH (2022). Nutraceutical activation of Sirt1: a review.. Open heart. DOI PubMed
  4. Wang M, Ren F, Zhou Y, He Y, et al. (2024). Age-related sarcopenia and altered gut microbiota: A systematic review.. Microbial pathogenesis. DOI PubMed
  5. Zhao H, Zhu H, Yun H, Liu J, et al. (2024). Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study.. Journal of the International Society of Sports Nutrition. DOI PubMed