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Types of Urolithin A: Forms & Bioavailability

Evidence:Insufficient
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Forms Comparison

FormBioavailabilityBest ForElemental Content
Urolithin A (Pure/Standardized)ModerateMitophagy induction, muscle endurance, and cellular longevityN/A
Ellagitannins (Precursor)LowSystemic antioxidant support and indirect Urolithin A productionVariable depending on source (e.g., pomegranate, raspberry)

Urolithin A (Pure/Standardized)

Bioavailability: Moderate. Best for: Mitophagy induction, muscle endurance, and cellular longevity. Elemental content: N/A.

Ellagitannins (Precursor)

Bioavailability: Low. Best for: Systemic antioxidant support and indirect Urolithin A production. Elemental content: Variable depending on source (e.g., pomegranate, raspberry).

Full Urolithin A Guide

References

  1. D'Amico D, Andreux PA, Valdés P, Singh A, et al. (2021). Impact of the Natural Compound Urolithin A on Health, Disease, and Aging.. Trends in molecular medicine. DOI PubMed
  2. Liu S, D'Amico D, Shankland E, Bhayana S, et al. (2022). Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial.. JAMA network open. DOI PubMed
  3. DiNicolantonio JJ, McCarty MF, O'Keefe JH (2022). Nutraceutical activation of Sirt1: a review.. Open heart. DOI PubMed
  4. Wang M, Ren F, Zhou Y, He Y, et al. (2024). Age-related sarcopenia and altered gut microbiota: A systematic review.. Microbial pathogenesis. DOI PubMed
  5. Zhao H, Zhu H, Yun H, Liu J, et al. (2024). Assessment of Urolithin A effects on muscle endurance, strength, inflammation, oxidative stress, and protein metabolism in male athletes with resistance training: an 8-week randomized, double-blind, placebo-controlled study.. Journal of the International Society of Sports Nutrition. DOI PubMed