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Vinpocetine Side Effects & Safety

Evidence:Moderate
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Safe with Caution

Potential Side Effects

  • Generally well-tolerated at recommended doses
  • Mild headache or dizziness
  • Facial flushing
  • Nausea or stomach discomfort
  • Transient drop in blood pressure
  • Caution: FDA warned in 2019 that vinpocetine may be unsafe during pregnancy

Drug & Supplement Interactions

  • Anticoagulants and antiplatelets — vinpocetine may have mild antiplatelet effects
  • Blood pressure medications — additive hypotensive effects possible
  • CYP3A4 substrates — vinpocetine may affect metabolism of certain drugs

Maximum Dose

Do not exceed: 30mg/day (higher doses not well-studied in supplements)

Full Vinpocetine Guide

References

  1. ReviewSzatmári S, Whitehouse P (2003). Vinpocetine for cognitive impairment and dementia. Cochrane Database of Systematic Reviews. DOI PubMed
  2. ReviewZhang YS, Li JD, Yan C (2018). An update on vinpocetine: new discoveries and clinical implications. European Journal of Pharmacology. DOI PubMed
  3. Meta-analysisPanda PK, Ramachandran A, Panda P, Sharawat IK (2022). Safety and Efficacy of Vinpocetine as a Neuroprotective Agent in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.. Neurocritical care. DOI PubMed
  4. Meta-analysisBereczki D, Fekete I (2008). Vinpocetine for acute ischaemic stroke.. The Cochrane database of systematic reviews. DOI PubMed
  5. RCTBereczki D, Fekete I (2000). Vinpocetine for acute ischaemic stroke.. The Cochrane database of systematic reviews. DOI PubMed
  6. ReviewBereczki D, Fekete I (1999). A systematic review of vinpocetine therapy in acute ischaemic stroke.. European journal of clinical pharmacology. DOI PubMed
  7. ReviewBagoly E, Fehér G, Szapáry L (2007). [The role of vinpocetine in the treatment of cerebrovascular diseases based in human studies].. Orvosi hetilap. DOI PubMed
Show 1 more reference
  1. Wang KN, Bell JS, Chen EYH, Gilmartin-Thomas JFM, et al. (2018). Medications and Prescribing Patterns as Factors Associated with Hospitalizations from Long-Term Care Facilities: A Systematic Review.. Drugs & aging. DOI PubMed