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Types of Vitamin B2 (Riboflavin): Forms & Bioavailability

Evidence:Strong
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Forms Comparison

FormBioavailabilityBest For
Riboflavin (Vitamin B2)ModerateGeneral supplementation — standard form, well-absorbed up to ~27 mg per dose
Riboflavin-5-Phosphate (R5P)HighBioactive form — already converted to coenzyme form, ideal for those with absorption issues

Riboflavin (Vitamin B2)

Bioavailability: Moderate. Best for: General supplementation — standard form, well-absorbed up to ~27 mg per dose.

Riboflavin-5-Phosphate (R5P)

Bioavailability: High. Best for: Bioactive form — already converted to coenzyme form, ideal for those with absorption issues.

References

  1. RCTSchoenen J, Jacquy J, Lenaerts M (1998). Effectiveness of high-dose riboflavin in migraine prophylaxis: a randomized controlled trial. Neurology. DOI PubMed
  2. ReviewThompson DF, Saluja HS (2017). Prophylaxis of migraine headaches with riboflavin: a systematic review. Journal of Clinical Pharmacy and Therapeutics. DOI PubMed
  3. ReviewPowers HJ (2003). Riboflavin (vitamin B-2) and health. American Journal of Clinical Nutrition. DOI PubMed
  4. RCTKałużna-Czaplińska J, Socha E, Rynkowski J (2011). B vitamin supplementation reduces excretion of urinary dicarboxylic acids in autistic children.. Nutrition research (New York, N.Y.). DOI PubMed