Skip to main content
Supplement ScienceSupplementScience

Types of Vitamin B3 (Niacin): Forms & Bioavailability

Evidence:Strong
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Forms Comparison

FormBioavailabilityBest For
Nicotinic Acid (Niacin)HighCholesterol management — the only form that significantly raises HDL; causes flushing
Niacinamide (Nicotinamide)HighSkin health and general use — no flushing, does not affect cholesterol
Nicotinamide Riboside (NR)HighNAD+ boosting and longevity research — efficient NAD+ precursor
Inositol Hexanicotinate (Flush-Free Niacin)LowThose wanting to avoid flushing — minimal evidence for cholesterol benefits

Nicotinic Acid (Niacin)

Bioavailability: High. Best for: Cholesterol management — the only form that significantly raises HDL; causes flushing.

Niacinamide (Nicotinamide)

Bioavailability: High. Best for: Skin health and general use — no flushing, does not affect cholesterol.

Nicotinamide Riboside (NR)

Bioavailability: High. Best for: NAD+ boosting and longevity research — efficient NAD+ precursor.

Inositol Hexanicotinate (Flush-Free Niacin)

Bioavailability: Low. Best for: Those wanting to avoid flushing — minimal evidence for cholesterol benefits.

References

  1. RCTAIM-HIGH Investigators, Boden WE, Probstfield JL, et al. (2011). Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. New England Journal of Medicine. DOI PubMed
  2. RCTChen AC, Martin AJ, Choy B, et al. (2015). A phase 3 randomized trial of nicotinamide for skin-cancer chemoprevention. New England Journal of Medicine. DOI PubMed
  3. RCTMartens CR, Denman BA, Mazzo MR, et al. (2018). Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nature Communications. DOI PubMed