Safety Profile
Overall safety rating: Generally Safe
Vitamin B5 (Pantothenic Acid) Side Effects & Safety
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Potential Side Effects
- Generally very well tolerated at standard doses
- Diarrhea and gastrointestinal distress at very high doses (>10 g/day)
- Contact dermatitis reported rarely with topical dexpanthenol
- Possible nausea at high oral doses
Drug & Supplement Interactions
- May enhance the effects of cholinesterase inhibitors (donepezil, rivastigmine)
- High doses may reduce absorption of biotin due to shared intestinal transport
- Tetracycline antibiotics — no significant known interactions
Maximum Dose
Do not exceed: No established upper limit; diarrhea and GI distress reported above 10 g/day
References
- Rumberger JA, Napolitano J, Azumano I, Kamiya T, Evans M (2011). Pantethine, a derivative of vitamin B5 used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects. Nutrition Research. DOI PubMed
- Proksch E, de Bony R, Trapp S, Boudon S (2017). Topical use of dexpanthenol: a 70th anniversary article. Journal of Dermatological Treatment. DOI PubMed
- Leung LH (1997). Pantothenic acid deficiency as the pathogenesis of acne vulgaris. Medical Hypotheses. DOI PubMed