General Dosage
500-1000mg daily for immune support
Maximum dose: 2000mg/day (tolerable upper intake level); higher doses may cause GI distress
Vitamin C Dosage Guide
Evidence:Strong
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Dosage Recommendations
General recommendation: 500-1000mg daily for immune support
Timing: Divided doses throughout the day for best absorption; with or without food
Dosage by Condition
Daily immune maintenance
200-500mg dailyStrong
Cold prevention
500-1000mg dailyStrong
Acute illness support
1000-2000mg daily in divided dosesModerate
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Daily immune maintenance | 200-500mg daily | Strong |
| Cold prevention | 500-1000mg daily | Strong |
| Acute illness support | 1000-2000mg daily in divided doses | Moderate |
Upper limit: 2000mg/day (tolerable upper intake level); higher doses may cause GI distress
Timing & Absorption
Divided doses throughout the day for best absorption; with or without food
Can be taken with or without food.
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References
- Meta-analysisHemila H, Chalker E (2013). Vitamin C for preventing and treating the common cold. Cochrane Database of Systematic Reviews. DOI PubMed
- ReviewCarr AC, Maggini S (2017). Vitamin C and immune function. Nutrients. DOI PubMed
- Bayu P, Wibisono JJ (2024). Vitamin C and E antioxidant supplementation may significantly reduce pain symptoms in endometriosis: A systematic review and meta-analysis of randomized controlled trials.. PloS one. DOI PubMed
- Ranjbar Moghaddam M, Nasiri-Formi E, Merajikhah A (2024). Efficacy of vitamin C supplementation in preventing and treating complex regional pain syndrome type I (CRPS-I) in Orthopedic patients: A systematic review and meta-analysis.. International journal of orthopaedic and trauma nursing. DOI PubMed
- Qi S, Luo X, Liu S, Ling B, et al. (2024). Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis.. BMJ open. DOI PubMed
- Meta-analysisZhong J, Li P, Zheng F, Li Y, et al. (2024). Association between dietary vitamin C intake/blood level and risk of digestive system cancer: a systematic review and meta-analysis of prospective studies.. Food & function. DOI PubMed
- ReviewSinopoli A, Sciurti A, Isonne C, Santoro MM, et al. (2024). The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prevention and Management of COVID-19 and Long-COVID: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials.. Nutrients. DOI PubMed