General Dosage
1,000-4,000 IU (25-100 mcg) daily with a fat-containing meal
Maximum dose: 4,000 IU/day (NIH Upper Tolerable Intake Level); up to 10,000 IU short-term under medical supervision
Vitamin D3 Dosage Guide
Evidence:Strong
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Dosage Recommendations
General recommendation: 1,000-4,000 IU (25-100 mcg) daily with a fat-containing meal
Timing: With the largest meal of the day for optimal absorption • Take with food for best absorption.
Dosage by Condition
Bone health
1,000-2,000 IU daily with calciumStrong
Immune support
1,000-4,000 IU dailyStrong
Depression
2,000-4,000 IU dailyModerate
Deficiency correction
5,000-10,000 IU daily for 8 weeks, then maintenanceStrong
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Bone health | 1,000-2,000 IU daily with calcium | Strong |
| Immune support | 1,000-4,000 IU daily | Strong |
| Depression | 2,000-4,000 IU daily | Moderate |
| Deficiency correction | 5,000-10,000 IU daily for 8 weeks, then maintenance | Strong |
Upper limit: 4,000 IU/day (NIH Upper Tolerable Intake Level); up to 10,000 IU short-term under medical supervision
Timing & Absorption
With the largest meal of the day for optimal absorption
Best taken with food for optimal absorption.
Find a Vitamin D3 with the right dose
We verify actual dosage against clinical research
References
- Meta-analysisMartineau AR, Jolliffe DA, Hooper RL, et al. (2017). Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. DOI PubMed
- RCTManson JE, Cook NR, Lee IM, et al. (2019). Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease. New England Journal of Medicine. DOI PubMed
- Anglin RE, Samaan Z, Walter SD, McDonald SD (2013). Vitamin D deficiency and depression in adults: systematic review and meta-analysis. British Journal of Psychiatry. DOI PubMed
- Meta-analysisTripkovic L, Lambert H, Hart K, et al. (2012). Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis. American Journal of Clinical Nutrition. DOI PubMed
- van den Heuvel EG, Lips P, Schoonmade LJ, Lanham-New SA, et al. (2024). Comparison of the Effect of Daily Vitamin D2 and Vitamin D3 Supplementation on Serum 25-Hydroxyvitamin D Concentration (Total 25(OH)D, 25(OH)D2, and 25(OH)D3) and Importance of Body Mass Index: A Systematic Review and Meta-Analysis.. Advances in nutrition (Bethesda, Md.). DOI PubMed
- Sobczak M, Pawliczak R (2024). Effect of Vitamin D3 Supplementation on Severe COVID-19: A Meta-Analysis of Randomized Clinical Trials.. Nutrients. DOI PubMed
- Tao X, Yang W, Zhang Q, Wang Y, et al. (2024). Effects of intermittent overload doses of oral vitamin D3 on serum 25(OH)D concentrations and the incidence rates of fractures, falls, and mortality in elderly individuals: A systematic review and meta-analysis.. Biomolecules & biomedicine. DOI PubMed
Show 5 more references
- Owczarek B, Ziomkiewicz A, Łukowska-Chojnacka E (2024). Has a High Dose of Vitamin D3 Impacted Health Conditions in Older Adults?-A Systematic Review and Meta-Analysis Focusing on Dose 100,000 IU.. Nutrients. DOI PubMed
- Meta-analysisManoj P, Derwin R, George S (2023). What is the impact of daily oral supplementation of vitamin D3 (cholecalciferol) plus calcium on the incidence of hip fracture in older people? A systematic review and meta-analysis.. International journal of older people nursing. DOI PubMed
- Meta-analysisKazemian E, Pourali A, Sedaghat F, Karimi M, et al. (2023). Effect of supplemental vitamin D3 on bone mineral density: a systematic review and meta-analysis.. Nutrition reviews. DOI PubMed
- Bislev LS, Wamberg L, Rolighed L, Grove-Laugesen D, et al. (2022). Effect of Daily Vitamin D3 Supplementation on Muscle Health: An Individual Participant Meta-analysis.. The Journal of clinical endocrinology and metabolism. DOI PubMed
- Sanabria A, Rojas A, Arevalo J (2019). Meta-analysis of routine calcium/vitamin D3 supplementation versus serum calcium level-based strategy to prevent postoperative hypocalcaemia after thyroidectomy.. The British journal of surgery. DOI PubMed