Skip to main content
Supplement ScienceSupplementScience

Vitamin E Side Effects & Safety

Evidence:Moderate
·

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Safe with Caution

Potential Side Effects

  • Increased all-cause mortality at doses ≥400 IU/day (Miller et al. 2005 meta-analysis)
  • Increased risk of hemorrhagic stroke at high doses
  • May increase prostate cancer risk in healthy men (SELECT trial, 2011)
  • GI discomfort (nausea, diarrhea) at high doses
  • Increased bleeding risk due to antiplatelet effects

Drug & Supplement Interactions

  • Anticoagulants (warfarin) — vitamin E enhances anticoagulant effects and increases bleeding risk
  • Chemotherapy and radiation — antioxidant effects may theoretically reduce treatment efficacy (consult oncologist)
  • Statins and niacin — vitamin E may reduce the HDL-raising benefit of niacin
  • Vitamin K — high-dose vitamin E may interfere with vitamin K-dependent clotting factors

Maximum Dose

Do not exceed: 1,000 mg/day (1,500 IU natural or 1,100 IU synthetic) NIH UL; meta-analyses suggest risk increases at ≥400 IU/day

Full Vitamin E Guide

References

  1. Meta-analysisMiller ER 3rd, Pastor-Barriuso R, Dalal D, et al. (2005). Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Annals of Internal Medicine. DOI PubMed
  2. Klein EA, Thompson IM Jr, Tangen CM, et al. (2011). Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. DOI PubMed
  3. RCTDysken MW, Sano M, Asthana S, et al. (2014). Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA. DOI PubMed
  4. Amin AM, Mostafa H (2026). Vitamin E and cognitive function: A systematic review of clinical evidence.. Nutrition research (New York, N.Y.). DOI PubMed
  5. Meta-analysisWen H, Deng H, Yang L, Li L, et al. (2024). Vitamin E for people with non-alcoholic fatty liver disease.. The Cochrane database of systematic reviews. DOI PubMed
  6. de Lima KS, Schuch F, Righi NC, Neto LJR, et al. (2024). Vitamin E Does not Favor Recovery After Exercises: Systematic Review and Meta-analysis.. International journal of sports medicine. DOI PubMed
  7. Meta-analysisQi S, Luo X, Liu S, Ling B, et al. (2024). Effect of vitamin B2, vitamin C, vitamin D, vitamin E and folic acid in adults with essential hypertension: a systematic review and network meta-analysis.. BMJ open. DOI PubMed
Show 4 more references
  1. Meta-analysisChee NM, Sinnanaidu RP, Chan WK (2024). Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.. Journal of gastroenterology and hepatology. DOI PubMed
  2. Xiong Z, Liu L, Jian Z, Ma Y, et al. (2023). Vitamin E and Multiple Health Outcomes: An Umbrella Review of Meta-Analyses.. Nutrients. DOI PubMed
  3. Vogli S, Naska A, Marinos G, Kasdagli MI, et al. (2023). The Effect of Vitamin E Supplementation on Serum Aminotransferases in Non-Alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-Analysis.. Nutrients. DOI PubMed
  4. Zhang T, Yi X, Li J, Zheng X, et al. (2023). Vitamin E intake and multiple health outcomes: an umbrella review.. Frontiers in public health. DOI PubMed