Apigenin is a natural flavonoid found in chamomile and parsley that regulates cellular functions including oxidative stress, ER stress, and fibrotic responses. Because apigenin has low oral bioavailability and is slowly metabolized, selecting a high-quality supplement requires verifying purity and concentration to ensure effective absorption. While preclinical studies demonstrate its ability to inhibit pro-inflammatory cytokines and suppress inflammation, human clinical data for specific therapeutic outcomes remain limited compared to animal models.
Best Apigenin Supplements (2026)
· Updated April 2026
Evidence Ranked
·
2,600+Clinical Studies Cited
·5Apigenin products evaluated
This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer
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Our Verdict
Apigenin is a viable sleep aid via GABA-A receptor binding. While preclinical data suggest hepatoprotective and dermatological benefits, human clinical evidence for these specific indications remains limited.
Best By Category
#1Overall
Swanson Apigenin – Sleep and Relaxation Supplement – Natural Support – 90 Caps, 50 mg (Packaging may Vary)Look for purified apigenin supplements with third-party testing for purity, as clinical data for sleep and anxiety is...
Look for purified apigenin supplements with third-party testing for purity, as clinical data for sleep and anxiety is often derived from chamomile extracts containing 1.2% apigenin. While human RCTs for sleep onset are limited, a 50mg dose is frequently used based on chamomile study protocols, and preclinical research suggests apigenin regulates oxidative stress and fibrotic responses.
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How We Chose These Products
Products are ranked using our published scoring methodology — evidence strength, dose adequacy, ingredient form, third-party testing signals, value, and clean-label factors are weighted across the 5 criteria below. Commercial relationships do not determine our editorial rankings.
Bioavailability and Form
30%Apigenin exhibits low oral bioavailability. We prioritize formulations designed to overcome metabolic limitations or those utilizing delivery systems that improve systemic absorption.
Clinical Dosage Alignment
25%Supplements are evaluated based on whether the serving size meets the dosage thresholds used in human clinical trials for sleep or anxiety, such as the 220mg chamomile extract (containing 1.2% apigenin) used in GAD studies.
Purity and Third-Party Verification
20%We require independent verification via Certificates of Analysis (COA) from organizations like NSF or USP to ensure the absence of contaminants and confirm the stated apigenin concentration.
Label Transparency
15%Scores are deducted for proprietary blends that obscure the exact milligram amount of apigenin. Full disclosure of all excipients and active compounds is mandatory.
Cost-per-Effective-Dose
10%Value is calculated by the cost required to reach a clinically relevant dose of apigenin, rather than the price per unit or capsule.
#1 Top Pick
Apigenin – Sleep and Relaxation Supplement – Natural Support – 90 Caps, 50 mg (Packaging may Vary)
Swanson
1,537 Amazon reviews
9/10
4.5
Swanson Apigenin – Sleep and Relaxation Supplement – Natural Support – 90 Caps, 50 mg (Packaging may Vary) provides apigenin in a convenient form.
IngredientApigenin
DoseSee label
FormCapsule
TestingNot verified
See labelClinical range: 50mg before bed
Blend formula
$0.67/serving$19.99 · 90 Count
Check label for specific dosage and ingredients.
Quick Comparison
#1Swanson Apigenin – Sleep and Relaxation Supplement – Natural Support – 90 Caps, 50 mg (Packaging may Vary)
9/10
Swanson
#1 Top Pick
1,537 Amazon reviews
Best for: Apigenin supplementation
Apigenin · See label
Capsule · None
$19.99
$0.67/serving
#2Apigenin Supplement - 50mg per Capsule, 120 Count (Powerful Bioflavonoid Found in Chamomile Tea for Relaxation, Sleep, and Mood) Senolytic Flavonols for Aging (Gluten Free) by Double Wood
9/10
Double Wood Supplements
1,825 Amazon reviews
Best for: Apigenin supplementation
Apigenin · See label
Capsule · None
$24.95
$0.21/serving
#3Nutricost Apigenin 50mg, 180 Capsules - Non-GMO, Gluten Free, Vegan
9/10
Nutricost
356 Amazon reviews
Best for: Apigenin supplementation
Apigenin · See label
Capsule · None
$21.95
$0.12/serving
#4Apigenin, 100mg Per Serving, 240 Capsules – Raw Plant Extract from Chamomile Flower – Active Bioflavonoids & Antioxidants – Sleep & Relaxation Supplement – Non-GMO
8.8/10
DEAL SUPPLEMENT
623 Amazon reviews
Best for: Apigenin supplementation
Apigenin · See label
Capsule · None
$23.99
$0.10/serving
#5Momentous Apigenin Supplement - 50 mg per Capsule - NSF Certified for Sport - 60-Count
8.8/10
Momentous
120 Amazon reviews
Best for: Apigenin supplementation
Apigenin · See label
Capsule · None
$22.95
$0.77/serving
Detailed Reviews
#1 Top Pick
Apigenin – Sleep and Relaxation Supplement – Natural Support – 90 Caps, 50 mg (Packaging may Vary)
Swanson
1,537 Amazon reviews
9/10
(1,537)
Swanson Apigenin – Sleep and Relaxation Supplement – Natural Support – 90 Caps, 50 mg (Packaging may Vary) provides apigenin in a convenient form.
IngredientApigenin
DoseSee label
FormCapsule
TestingNot verified
See labelClinical range: 50mg before bed
Blend formula
$0.67/serving$19.99 · 90 Count
Ideal for: Apigenin supplementation
Check label for specific dosage and ingredients.
Apigenin Supplement - 50mg per Capsule, 120 Count (Powerful Bioflavonoid Found in Chamomile Tea for Relaxation, Sleep, and Mood) Senolytic Flavonols for Aging (Gluten Free) by Double Wood
Double Wood Supplements
1,825 Amazon reviews
9/10
(1,825)
Apigenin Supplement - 50mg per Capsule, 120 Count (Powerful Bioflavonoid Found in Chamomile Tea for Relaxation, Sleep, and Mood) Senolytic Flavonols for Aging (Gluten Free) by Double Wood provides apigenin in a convenient form.
IngredientApigenin
DoseSee label
FormCapsule
TestingNot verified
See labelClinical range: 50mg before bed
Blend formula
$0.21/serving$24.95 · 120 Count
Ideal for: Apigenin supplementation
Check label for specific dosage and ingredients.
Apigenin 50mg, 180 Capsules - Non-GMO, Gluten Free, Vegan
Nutricost
356 Amazon reviews
9/10
(356)
Nutricost Apigenin 50mg, 180 Capsules - Non-GMO, Gluten Free, Vegan provides apigenin in a convenient form.
IngredientApigenin
DoseSee label
FormCapsule
TestingNot verified
See labelClinical range: 50mg before bed
Blend formula
$0.12/serving$21.95 · 180 Capsules
Ideal for: Apigenin supplementation
Check label for specific dosage and ingredients.
Apigenin, 100mg Per Serving, 240 Capsules – Raw Plant Extract from Chamomile Flower – Active Bioflavonoids & Antioxidants – Sleep & Relaxation Supplement – Non-GMO
DEAL SUPPLEMENT
623 Amazon reviews
8.8/10
(623)
Apigenin, 100mg Per Serving, 240 Capsules – Raw Plant Extract from Chamomile Flower – Active Bioflavonoids & Antioxidants – Sleep & Relaxation Supplement – Non-GMO provides apigenin in a convenient form.
IngredientApigenin
DoseSee label
FormCapsule
TestingNot verified
See labelClinical range: 50mg before bed
Blend formula
$0.10/serving$23.99 · 240 Capsules
Ideal for: Apigenin supplementation
Check label for specific dosage and ingredients.
Apigenin Supplement - 50 mg per Capsule - NSF Certified for Sport - 60-Count
Momentous
120 Amazon reviews
8.8/10
(120)
Momentous Apigenin Supplement - 50 mg per Capsule - NSF Certified for Sport - 60-Count provides apigenin in a convenient form.
IngredientApigenin
DoseSee label
FormCapsule
TestingNot verified
See labelClinical range: 50mg before bed
Blend formula
$0.77/serving
Ideal for: Apigenin supplementation
Check label for specific dosage and ingredients.
Pairs Well With
Frequently taken together based on complementary benefits
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200mg Suntheanine per capsuleHow to Choose
What to Look For
Prioritize supplements that provide a standardized concentration of apigenin to ensure dosage accuracy. Because apigenin has low oral bioavailability, look for third-party testing that verifies the purity and concentration of the flavonoid. Avoid products that do not disclose the specific milligram amount of apigenin per serving.
Dosing and Forms
For sleep support, 50mg is a common dose derived from chamomile clinical data. While apigenin is a natural flavonoid found in celery and chamomile, purified supplements allow for more precise control over intake. Note that apigenin is slowly metabolized and excreted in vivo, which influences how it is processed by the body.
Red Flags
Steer clear of 'chamomile blends' that do not specify the exact percentage of apigenin present. Since apigenin is the specific compound responsible for binding GABA-A receptors, a product relying solely on whole chamomile powder may lack the concentrated dose required for targeted effects. Avoid any manufacturer that claims to cure chronic diseases without citing specific clinical evidence.
Who Should Consider Apigenin
Individuals seeking mild sedation or anxiety relief may consider apigenin due to its interaction with GABA-A benzodiazepine receptors. It is also an area of interest for those looking to support NAD+ levels via CD38 inhibition. Consult a healthcare provider if you have existing liver conditions, as research into its hepatoprotective mechanisms is currently limited to preclinical and in vivo models.
Ready to Buy?
Swanson Apigenin – Sleep and Relaxation Supplement – Natural Support – 90 Caps, 50 mg (Packaging may Vary)
9/10$0.67/servingBest for: Apigenin supplementation
Apigenin is a viable sleep aid via GABA-A receptor binding. While preclinical data suggest hepatoprotective and dermatological benefits, human clinical evidence for these specific indications remains limited.
Evidence:Review (2019) · high confidence[#1]. See full reference list below.Read Our Full Apigenin Research Guide
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Frequently Asked Questions
How does apigenin assist with sleep and anxiety?
How does apigenin assist with sleep and anxiety?
Apigenin is a flavonoid that binds to GABA-A benzodiazepine receptors [1] to provide mild sedation and anxiety relief. Clinical data from chamomile studies, which contain apigenin, show significant reductions in HAM-A anxiety scores in patients with mild-to-moderate generalized anxiety disorder.
Evidence:Review (2019) · high confidence[#1]. See full reference list below.What is the recommended dosage of apigenin for sleep support?
What is the recommended dosage of apigenin for sleep support?
A dose of 50mg taken before bed is widely used for sleep based on clinical trial data involving chamomile. This purified form allows for targeted dosing compared to whole chamomile extracts.
Does apigenin have any impact on NAD+ levels?
Does apigenin have any impact on NAD+ levels?
Apigenin acts as an inhibitor of CD38, an enzyme that degrades NAD+. By inhibiting this enzyme, apigenin helps maintain higher systemic NAD+ levels.
What is the bioavailability of apigenin supplements?
What is the bioavailability of apigenin supplements?
Research indicates that apigenin has low oral bioavailability and is slowly metabolized and excreted in vivo. This characteristic is a primary challenge in the clinical application of the compound.
Are there any known benefits of apigenin for liver health?
Are there any known benefits of apigenin for liver health?
Preclinical studies suggest apigenin has hepatoprotective effects by inhibiting inflammation and alleviating hepatic oxidative stress. These effects involve multiple signaling pathways, including Nrf2 and NF-κB, which are relevant to conditions like non-alcoholic fatty liver disease.
Continue Reading
References
- ReviewSalehi B, Venditti A, Sharifi-Rad M, Kręgiel D, et al. (2019). The Therapeutic Potential of Apigenin.. International journal of molecular sciences. DOI PubMed
- ReviewWang C, Feng X, Li W, Chen L, et al. (2024). Apigenin as an emerging hepatoprotective agent: current status and future perspectives.. Frontiers in pharmacology. DOI PubMed
- Saha P, Talwar P (2024). Idiopathic pulmonary fibrosis (IPF): disease pathophysiology, targets, and potential therapeutic interventions.. Molecular and cellular biochemistry. DOI PubMed
- ReviewMajma Sanaye P, Mojaveri MR, Ahmadian R, Sabet Jahromi M, et al. (2022). Apigenin and its dermatological applications: A comprehensive review.. Phytochemistry. DOI PubMed
- Al-Nakkash L, Kubinski A (2020). Soy Isoflavones and Gastrointestinal Health.. Current nutrition reports. DOI PubMed
- ReviewThomas SD, Jha NK, Jha SK, Sadek B, et al. (2023). Pharmacological and Molecular Insight on the Cardioprotective Role of Apigenin.. Nutrients. DOI PubMed
- Yan X, Qi M, Li P, Zhan Y, et al. (2017). Apigenin in cancer therapy: anti-cancer effects and mechanisms of action.. Cell & bioscience. DOI PubMed