Integrative Therapeutics Neurologix - with Saffron and CDP-Choline - Nootropic Supplement for Brain Health*- Focus* - Memory Support* - Vegan, Gluten-Free & Dairy-Free - 28 Capsules (14 Servings)
$0.94/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
2 capsules per serving; 14 servings per 28-count bottle of Cognizin CDP-Choline + Saffron extract + Spearmint extract (Neumentix) per capsule from Integrative Therapeutics. Best for adults seeking a non-stimulant…
Why we recommend this
Neurologix stands out in the nootropic category for its use of Cognizin — the most clinically documented CDP-choline form on the market — paired with saffron extract, which has genuine human clinical evidence for both mood and cognitive function. The non-stimulant mechanism is a meaningful advantage for users who are caffeine-sensitive. Integrative Therapeutics' 45-year clinical manufacturing pedigree adds credibility.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
The 28-capsule / 14-serving bottle size is the most significant practical drawback — daily users go through a bottle in two weeks, driving up cost and inconvenience. A 60-day supply would require purchasing four bottles. The 4.3-star rating, while solid, reflects some user variability in perceived cognitive effects.
Dose & form
- Serving
- 2 capsules per serving; 14 servings per 28-count bottle
- Form
- Capsule
- Clinical range
- Cognizin CDP-Choline studied at 250-500mg/day; saffron studied at 28-30mg/day for mood and cognition
- Dose adequacy
- Blend
- Supply
- 28 servings · $0.94/serving
Who it's best for
Adults seeking a non-stimulant nootropic with clinically validated CDP-choline and saffron for focus, memory, and positive mood
Who should skip it
Users wanting a simple single-ingredient nootropic or anyone needing more than a 14-serving supply per bottle
Pros
- Cognizin CDP-Choline — a clinically validated, branded ingredient with human trial data for brain energy and frontal lobe bioenergetics
- Saffron extract at clinically researched doses supports positive mood and cognitive function alongside nootropic ingredients
- Non-stimulant formula — supports focus and working memory without caffeine or adrenergic compounds
- Vegan, gluten-free, corn-free, and soy-free — among the cleanest allergen profiles in the clinical nootropic category
Cons
- Only 14 servings per bottle — extremely short supply for daily users requiring frequent repurchasing
- 193 reviews at 4.3 stars is a modest rating for the nootropic category, with some mixed effectiveness reports
- Premium price per serving given the 14-serving bottle size
What customers say
4.3★ across 193 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Cognizin CDP-Choline + Saffron extract + Spearmint extract (Neumentix)?
What is the clinical dose for Cognizin CDP-Choline + Saffron extract + Spearmint extract (Neumentix)?
Clinical trials typically use Cognizin CDP-Choline studied at 250-500mg/day; saffron studied at 28-30mg/day for mood and cognition. Integrative Therapeutics Neurologix delivers 2 capsules per serving; 14 servings per 28-count bottle, which we classify as Blend relative to that range.
How does Integrative Therapeutics Neurologix compare to similar Capsule?
How does Integrative Therapeutics Neurologix compare to similar Capsule?
See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.
Is Integrative Therapeutics Neurologix third-party tested?
Is Integrative Therapeutics Neurologix third-party tested?
Yes — GMP-manufactured, bottled and tested in the USA; Cognizin is a patented clinically studied ingredient. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
Saffron extract at clinical doses (28-30mg) may interact with antidepressants (SSRIs) — combining saffron with SSRIs has been studied for additive mood effects, but consult your psychiatrist before combining. CDP-choline may modestly affect acetylcholine levels, which could interact with anticholinergic medications used for bladder, COPD, or motion sickness. Spearmint extract is generally low-risk for drug interactions.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
CDP-choline has been studied for up to 90 days in clinical trials with no significant adverse effects at 250-1000mg daily. Saffron at 28-30mg daily is well tolerated in trials up to 8-12 weeks; higher doses (>5g) are toxic, but supplement doses are far below this threshold. Spearmint extract has a strong safety record. Long-term continuous use is considered safe at labeled doses.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
CDP-choline occasionally causes mild nausea, headache, or insomnia at higher doses — at 250-500mg, these effects are rare. Saffron may cause mild GI discomfort in a small percentage of users, particularly on an empty stomach. Most Neurologix users report good tolerability; taking with food minimizes GI sensitivity from any of the three active ingredients.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
Neurologix pairs well with omega-3 fatty acids and a B-complex for comprehensive brain health support. Avoid stacking with other CDP-choline or choline sources (lecithin, alpha-GPC) without calculating total daily choline to stay within the 550mg tolerable upper intake. Additional saffron supplements should not be combined. Coffee or caffeine can be used alongside Neurologix as it is stimulant-free.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Take 2 capsules daily with or without food. Do not exceed the recommended dose. Pregnant or nursing women should not use saffron-containing supplements without physician clearance, as saffron has historically been associated with uterine stimulation at high doses. Keep out of reach of children.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
CDP-choline's brain energy effects may be noticed acutely within hours to days for some users, while working memory and frontal lobe bioenergetics improvements emerge after 4-6 weeks of consistent use in clinical trials. Saffron's mood and cognitive benefits appear after 2-8 weeks based on clinical research. Spearmint phenolics for sustained focus typically show effects after 30+ days of daily use.
