Integrative Therapeutics Betaine HCl - Digestive Support Supplement for Healthy Stomach Acidity* - Supports Gastric Function & Protein Digestion* - Dairy-Free - 250 Capsules (125 Servings)
$0.18/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
2 capsules per serving (250 capsules, 125 servings) of Betaine HCl + Pepsin per capsule from Integrative Therapeutics. Best for adults with low stomach acid (hypochlorhydria) needing support for gastric…
Why we recommend this
Integrative Therapeutics Betaine HCl + Pepsin is a practitioner-channel standard for hypochlorhydria management. The combination reflects clinical knowledge about the complementary roles of stomach acid and proteolytic enzymes, appropriate for healthcare-supervised contexts.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
Betaine HCl supplementation requires careful patient selection - inappropriate use in those with ulcers or active GERD can cause serious GI burning. Pepsin is animal-derived limiting vegan compatibility.
Dose & form
- Serving
- 2 capsules per serving (250 capsules, 125 servings)
- Form
- Capsule
- Clinical range
- Betaine HCl typically 650-1300mg per meal; pepsin 40-200mg complementary
- Dose adequacy
- Full
- Supply
- 250 servings · $0.18/serving
- UPC
- 871791002364
Who it's best for
Adults with low stomach acid (hypochlorhydria) needing support for gastric function, protein digestion, and nutrient absorption
Who should skip it
Individuals with gastritis, peptic ulcers, GERD, or taking NSAIDs/corticosteroids - betaine HCl can worsen these conditions
Pros
- Betaine HCl + pepsin is the clinical standard for low stomach acid supplementation
- 250-capsule bottle provides 125 servings - excellent supply per purchase
- 133 reviews at 4.5 stars from an informed gastric-health buyer base
- Practitioner-grade formula from a brand with 45+ years in clinical nutrition
Cons
- Contraindicated in peptic ulcers, gastritis, and users of NSAIDs/corticosteroids
- Per-capsule HCl dose not disclosed - clinical dose titration harder without this
- Pepsin is animal-derived - not suitable for strict vegans
What customers say
4.5★ across 133 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Betaine HCl + Pepsin?
What is the clinical dose for Betaine HCl + Pepsin?
Clinical trials typically use Betaine HCl typically 650-1300mg per meal; pepsin 40-200mg complementary. IT Betaine HCl with Pepsin delivers 2 capsules per serving (250 capsules, 125 servings), which we classify as Full relative to that range.
How does IT Betaine HCl with Pepsin compare to similar Capsule?
How does IT Betaine HCl with Pepsin compare to similar Capsule?
See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.
Is IT Betaine HCl with Pepsin third-party tested?
Is IT Betaine HCl with Pepsin third-party tested?
Yes — GMP Certified. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
Betaine HCl can interact with NSAIDs, aspirin, and corticosteroids - co-administration increases risk of gastric irritation. Do not use if taking PPIs or H2 blockers as HCl supplementation directly counteracts these medications. Consult your prescriber before use.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
Long-term betaine HCl use is appropriate for confirmed hypochlorhydria under healthcare guidance. Extended use without reassessment may maintain dependency on supplemental acid. Periodic HCl challenge testing is recommended by some practitioners.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
A burning sensation after taking betaine HCl indicates adequate or excessive stomach acid - in this case the supplement is not needed. Users with genuinely low stomach acid typically feel no burning or feel improved digestion. Starting with 1 capsule and titrating upward is the clinical standard.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
Betaine HCl pairs with digestive enzymes for comprehensive upper GI support. Do not combine with antacids - they directly neutralize the supplemental HCl. Zinc and magnesium may absorb better with improved gastric acidity. Vitamin B12 absorption can also improve with restored stomach acid.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Take 1-2 capsules with protein-containing meals only. Begin with 1 capsule per meal and increase gradually, stopping if you feel a burning sensation. Never use without healthcare guidance if you have any GI conditions.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
Improvements in protein digestion and nutrient absorption are typically experienced within the first 1-2 weeks of use with meals. Reduced bloating, improved food tolerance, and better post-meal energy are the most commonly reported acute benefits.
