Integrative Therapeutics Indolplex – 240mg Bioavailable DIM for Hormone Balance Support* - Supports Estrogen Metabolism* - Gluten-Free & Dairy-Free - 60 Capsules (30 Servings)
$0.84/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
240mg BR-DIM per serving (2 capsules); 30 servings per 60-count bottle of BR-DIM (bioavailable diindolylmethane) 240mg per serving per capsule from Integrative Therapeutics. Best for adults seeking clinically studied BR-DIM…
Why we recommend this
Indolplex uses BR-DIM, a microencapsulated form shown in clinical studies to shift the estrogen metabolite ratio more effectively than standard DIM. Integrative Therapeutics practitioner-grade manufacturing and the clinically validated ingredient form justify the premium positioning.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
At $50.25 for 30 servings, Indolplex is one of the pricier products in this batch on a per-serving basis. The modest 153-review count limits broad real-world effectiveness assessment. The proprietary BR-DIM form is justified by bioavailability evidence but commands a price premium.
Dose & form
- Serving
- 240mg BR-DIM per serving (2 capsules); 30 servings per 60-count bottle
- Form
- Capsule
- Clinical range
- BR-DIM studied at 75-300mg/day for estrogen metabolite ratio support; 240mg/day is within the clinically studied range
- Dose adequacy
- Full
- Supply
- 60 servings · $0.84/serving
- UPC
- 871791000483
Who it's best for
Adults seeking clinically studied BR-DIM (bioavailable diindolylmethane) for estrogen metabolism support in both men and women
Who should skip it
Those wanting a standard DIM product — Indolplex uses the proprietary BR-DIM microencapsulated form at a premium price
Pros
- BR-DIM microencapsulated form with demonstrated clinical bioavailability advantage over standard DIM
- Clinically studied for estrogen metabolite ratio in both men and women
- 240mg/day dose within the range used in published clinical research
- Gluten-free, dairy-free with no artificial additives
Cons
- 153 reviews — modest social proof relative to the price point ($50.25)
- Two-capsule serving — not single-capsule convenience
- Premium price for a 30-serving bottle
What customers say
4.5★ across 153 Amazon reviews. The most common questions from shoppers: re any potential interactions with medications, re any side effects from long-term use, and cause any digestive issues or side effects. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for BR-DIM (bioavailable diindolylmethane) 240mg per serving?
What is the clinical dose for BR-DIM (bioavailable diindolylmethane) 240mg per serving?
Clinical trials typically use BR-DIM studied at 75-300mg/day for estrogen metabolite ratio support; 240mg/day is within the clinically studied range. IT Indolplex DIM 240mg Capsules (60ct / 30srv) delivers 240mg BR-DIM per serving (2 capsules); 30 servings per 60-count bottle, which we classify as Full relative to that range.
How does IT Indolplex DIM 240mg Capsules (60ct / 30srv) compare to similar Capsule?
How does IT Indolplex DIM 240mg Capsules (60ct / 30srv) compare to similar Capsule?
See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.
Is IT Indolplex DIM 240mg Capsules (60ct / 30srv) third-party tested?
Is IT Indolplex DIM 240mg Capsules (60ct / 30srv) third-party tested?
Yes — GMP Certified. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Are there any potential interactions with medications?
Are there any potential interactions with medications?
DIM can affect CYP1A2 enzyme activity, potentially interacting with medications metabolized by this pathway including some antidepressants, antipsychotics, and caffeine. It may also affect thyroid function in some individuals. Consult your physician if on these medications or with thyroid conditions.
Are there any side effects from long-term use?
Are there any side effects from long-term use?
BR-DIM at 240mg/day is well tolerated in clinical studies. Some users report mild GI discomfort, headache, or darkened urine during initial use. These effects are typically transient. Long-term use warrants periodic estrogen metabolite monitoring with a practitioner.
Does it cause any digestive issues or side effects?
Does it cause any digestive issues or side effects?
DIM supplements occasionally cause mild GI discomfort, headache, or nausea during initial weeks of use. The microencapsulated BR-DIM form may reduce GI effects compared to standard DIM. Taking with food as directed minimizes most GI side effects.
Can it be taken with other supplements or vitamins?
Can it be taken with other supplements or vitamins?
DIM combines logically with calcium D-glucarate for comprehensive estrogen detoxification support. Compatible with standard vitamins and minerals. Avoid stacking with other strong CYP1A2-modulating supplements without practitioner guidance.
Are there any specific instructions for taking it safely?
Are there any specific instructions for taking it safely?
Take 2 capsules daily with food per the label. Food co-ingestion supports absorption of the microencapsulated BR-DIM form. Not for use during pregnancy. Consult a practitioner for baseline estrogen metabolite assessment before starting for hormone balance applications.
How long until benefits are typically experienced?
How long until benefits are typically experienced?
Estrogen metabolite ratio shifts from BR-DIM supplementation are typically assessed after 4-8 weeks of consistent use. Some practitioners run urinary estrogen metabolite testing at baseline and 8 weeks to confirm response. Subjective hormone balance effects may be noticed within 4-6 weeks.
