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NatureWise Vitamin D3 5000 IU — view 1 of 5
NatureWise

NatureWise Vitamin D3 5000iu (125 mcg) 1 Year Supply for Immune Support, Healthy Muscle Function, and Bone Health - Non-GMO, Gluten Free in Organic Extra Virgin Olive Oil, (Mini Softgel), 360 Count

4.7· 191,874 Amazon reviews
$14.99$14.24with Subscribe & Save

$0.04/serving

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Price verified Apr 22, 2026

Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use

Our verdict

5,000 IU (125mcg) of Vitamin D3 (Cholecalciferol) in Organic Olive Oil per softgel from NatureWise. Best for best value vitamin D3.

Third-Party TestedGluten-freeNon-GMOSoftgelSubscribe & Save

Why we recommend this

America's #1 best-selling vitamin D brand with 60,000+ reviews. Organic olive oil carrier for absorption. Exceptional value at about 5 cents per day.

Check for interactions

Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.

Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.

What to watch out for

No added K2 — consider supplementing separately if taking calcium.

Dose & form

Serving
5,000 IU (125mcg)
Form
Softgel
Clinical range
1,000-4,000 IU daily (25-100 mcg)
Dose adequacy
Full
Supply
360 servings · $0.04/serving
UPC
858081006042

Who it's best for

Best value vitamin D3

Who should skip it

People supplementing calcium who need K2 co-factor

Pros

  • #1 best-selling vitamin D brand
  • Incredible value ($0.05/serving)
  • Organic olive oil carrier
  • 60,000+ reviews

Cons

  • No K2 included
  • May need separate K2 supplement

What customers say

4.7★ across 191,874 Amazon reviews. The most common questions from shoppers: naturewise vitamin d3 5000 iu safe to take daily, naturewise vitamin d3 5000 iu cause vitamin d toxicity, and naturewise vitamin d3 5000 iu safe during pregnancy. Full answers in the FAQ below.

Frequently Asked Questions

What is the clinical dose for Vitamin D3 (Cholecalciferol) in Organic Olive Oil?

Clinical trials typically use 1,000-4,000 IU daily (25-100 mcg). NatureWise Vitamin D3 5000 IU delivers 5,000 IU (125mcg), which we classify as Full relative to that range.

How does NatureWise Vitamin D3 5000 IU compare to similar Softgel?

See the "Also consider" section below for two alternatives. Choose based on form preference (Softgel vs alternatives), dose adequacy, and third-party testing.

Is NatureWise Vitamin D3 5000 IU third-party tested?

Yes — Third-Party Tested, Non-GMO. Third-party testing verifies ingredient identity and label accuracy.

Does this work with Amazon Subscribe & Save?

Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.

Is NatureWise Vitamin D3 5000 IU safe to take daily?

Yes, NatureWise Vitamin D3 5000 IU is designed for daily use at the recommended serving size. NatureWise follows Good Manufacturing Practices (GMP), and the product has been well-tolerated in thousands of customer reviews.

Can NatureWise Vitamin D3 5000 IU cause vitamin D toxicity?

Vitamin D toxicity is rare and typically occurs only at sustained intakes above 10,000 IU daily without medical supervision. At 5,000 IU (125mcg), this product is within safe limits for most adults, but you should test your serum 25(OH)D levels periodically.

Is NatureWise Vitamin D3 5000 IU safe during pregnancy?

Vitamin D supplementation is generally recommended during pregnancy, but doses above 2,000 IU should be discussed with your OB-GYN. The American College of Obstetricians and Gynecologists recommends at least 600 IU daily for pregnant women.

Does NatureWise Vitamin D3 5000 IU interact with medications?

Vitamin D can interact with certain medications including thiazide diuretics, corticosteroids, and weight-loss drugs like orlistat. Consult your healthcare provider if you take prescription medications.

Are there side effects from taking NatureWise Vitamin D3 5000 IU?

Side effects are uncommon at recommended doses. Very high doses of vitamin D may cause nausea, constipation, or elevated calcium levels. Start at the recommended serving and monitor how you feel during the first two weeks.

How many servings are in one bottle of NatureWise Vitamin D3 5000 IU?

Each bottle contains 360 servings. At one serving per day, this provides approximately 12 months of daily supplementation.

Also consider

Part of this guide

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As an Amazon Associate, we earn from qualifying purchases. Some links below are affiliate links — this doesn't affect our editorial independence or product ratings. How we evaluate products

This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer