Optimum Nutrition HMB 1000 Caps, 1g of Calcium beta-Hydroxy beta-methylbutyrate per Capsule, 90 Capsules, 30 Servings
$0.44/serving
Price verified Apr 22, 2026
Not evaluated by the FDA · Individual results may vary · Consult a healthcare provider before use
Our verdict
1000mg calcium HMB per capsule of Calcium HMB (beta-hydroxy beta-methylbutyrate) per capsule from Optimum Nutrition. Best for overall best HMB capsule for muscle preservation.
Why we recommend this
Delivers a full 1g calcium HMB per capsule — just three capsules daily hits the clinical 3g dose. Informed Choice certified for banned substance testing. Optimum Nutrition is the most trusted sports nutrition brand worldwide. Simple, clean formula with no unnecessary additives.
Check for interactions
Already taking other supplements or prescription medications? Add them below to check for documented interactions, severity, and clinical guidance.
Our database currently documents 137+ supplement and drug-category interaction pairs. Combinations not flagged here may still interact — always consult your healthcare provider before combining supplements, especially with prescription medications.
What to watch out for
Three capsules daily needed for clinical dose. More expensive per gram than bulk powder. Calcium HMB form absorbs slower than free acid (but this rarely matters practically).
Dose & form
- Serving
- 1000mg calcium HMB per capsule
- Form
- Capsule
- Clinical range
- 3 g daily
- Dose adequacy
- Subtherapeutic
- Supply
- 90 servings · $0.44/serving
- UPC
- 748927023138
Who it's best for
Overall best HMB capsule for muscle preservation
Who should skip it
Those wanting the cheapest per-gram price (powder is cheaper).
Pros
- 1g per capsule (3 caps = clinical dose)
- Informed Choice certified
- Trusted ON brand
- Clean single-ingredient formula
Cons
- Three capsules daily required
- More expensive than powder form
- Calcium HMB (slower absorption than free acid)
What customers say
4.5★ across 2,108 Amazon reviews. The most common questions from shoppers: hmb safe to take long-term, hmb interact with medications, and re side effects from taking optimum nutrition hmb. Full answers in the FAQ below.
Frequently Asked Questions
What is the clinical dose for Calcium HMB (beta-hydroxy beta-methylbutyrate)?
What is the clinical dose for Calcium HMB (beta-hydroxy beta-methylbutyrate)?
Clinical trials typically use 3 g daily. Optimum Nutrition HMB 1000mg delivers 1000mg calcium HMB per capsule, which we classify as Subtherapeutic relative to that range.
How does Optimum Nutrition HMB 1000mg compare to similar Capsule?
How does Optimum Nutrition HMB 1000mg compare to similar Capsule?
See the "Also consider" section below for two alternatives. Choose based on form preference (Capsule vs alternatives), dose adequacy, and third-party testing.
Is Optimum Nutrition HMB 1000mg third-party tested?
Is Optimum Nutrition HMB 1000mg third-party tested?
Yes — Informed Choice Certified. Third-party testing verifies ingredient identity and label accuracy.
Does this work with Amazon Subscribe & Save?
Does this work with Amazon Subscribe & Save?
Yes — Amazon Subscribe & Save is available for this product. Enrolling locks in a recurring delivery at a reduced per-unit price.
Is HMB safe to take long-term?
Is HMB safe to take long-term?
HMB has been studied in clinical trials lasting up to 12 months with no significant adverse effects reported. It is a natural metabolite of the amino acid leucine that your body already produces in small amounts. Long-term supplementation at the standard 3g daily dose is generally considered safe for healthy adults.
Can HMB interact with medications?
Can HMB interact with medications?
There are no well-documented drug interactions with HMB supplementation. However, because HMB contains calcium, those taking calcium channel blockers or other calcium-sensitive medications should consult their healthcare provider. It is always best to discuss any new supplement with your doctor if you take prescription medications.
Are there side effects from taking Optimum Nutrition HMB?
Are there side effects from taking Optimum Nutrition HMB?
HMB is well-tolerated at the recommended 3g daily dose. Some users occasionally report mild stomach discomfort when taking capsules on an empty stomach. Taking the capsules with meals typically prevents any digestive issues.
Is this HMB supplement safe for tested athletes?
Is this HMB supplement safe for tested athletes?
Yes, Optimum Nutrition HMB is Informed Choice certified, meaning every batch is tested for banned substances by an independent lab. This makes it suitable for athletes subject to drug testing by WADA, NCAA, or other sports organizations.
Can pregnant or breastfeeding women take HMB?
Can pregnant or breastfeeding women take HMB?
There is insufficient research on HMB use during pregnancy or breastfeeding. While HMB is a naturally occurring compound, pregnant or nursing women should consult their healthcare provider before starting supplementation. Most sports supplements are not specifically tested for safety in these populations.
What is the recommended daily dose of HMB?
What is the recommended daily dose of HMB?
The clinically studied dose is 3g of calcium HMB per day. With Optimum Nutrition HMB at 1g per capsule, this means taking three capsules daily. Splitting the dose across three meals helps maintain steady blood levels throughout the day.
Also consider
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