Sports Research® Magnesium Glycinate - Supports Restful Sleep & Enzymatic Processes - 160 mg Chelated Magnesium - Liquid Softgel - 60 Count

Clinical trials typically use 200-400mg elemental magnesium daily. Sports Research Magnesium Glycinate 160mg Liquid Softgels delivers 160mg chelated magnesium glycinate per softgel, which we classify as Partial relative to that range.

See the "Also consider" section below for two alternatives. Choose based on form preference (Liquid Softgel vs alternatives), dose adequacy, and third-party testing.

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Magnesium glycinate may enhance the effect of blood pressure medications, muscle relaxants, and sedatives — consult your physician if you take these. Separate intake from antibiotics (fluoroquinolones, tetracyclines) and bisphosphonates by at least 2 hours to prevent reduced drug absorption. Unlike oxide, glycinate's GI-gentle absorption means reduced local drug interference, but systemic magnesium interactions still apply.

Magnesium glycinate is the most well-tolerated magnesium form for long-term daily use — the glycine chelation is absorbed completely in the small intestine without the osmotic laxative effect of oxide. Long-term safety is well-documented. Those with kidney disease should still monitor magnesium levels periodically, as impaired renal excretion is the primary risk in any magnesium form.

Minimal — magnesium glycinate is specifically chosen over oxide and citrate precisely because it avoids osmotic GI effects. The glycinate chelate is fully absorbed in the upper GI tract, leaving no residual magnesium to reach the colon and cause loose stools. A small number of users report mild nausea when taken on an empty stomach, which resolves with food co-ingestion.

Highly compatible with vitamin D3 (supports magnesium metabolism), vitamin K2 (bone synergy), and L-theanine or ashwagandha for enhanced relaxation and sleep stacking. Magnesium glycinate pairs well with the Sports Research Ashwagandha Shoden softgel for a comprehensive sleep and stress-support regimen. Avoid stacking with other high-dose magnesium forms to stay within the 400mg/day total limit.

Take one to two softgels daily — one for general mineral support, two for sleep or therapeutic applications. Take in the evening 30–60 minutes before bed if using for sleep support. Do not exceed 400mg magnesium total from all supplement sources per day without medical guidance. Individuals with kidney disease must consult their physician before use.

Sleep quality improvements from magnesium glycinate are typically reported within 1–2 weeks of nightly use — faster than oxide forms due to superior bioavailability. Magnesium glycinate clinical trials at 200–350mg/day show measurable improvements in sleep onset and maintenance within 4–8 weeks. Subjective relaxation and reduction in nighttime muscle tension can appear within the first few days for magnesium-deficient individuals.