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meta analysis1,924 participants

Psyllium Husk for LDL Cholesterol: Meta-Analysis of 28 Trials

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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

A meta-analysis of 28 trials involving 1,924 participants found an average LDL reduction of 0.33 mmol/L (about 13...

A meta-analysis of 28 trials involving 1,924 participants found an average LDL reduction of 0.33 mmol/L (about 13 mg/dL) at a median psyllium dose of 10.2 g/day. The LDL evidence was graded moderate; an individual response or a best dose is not guaranteed [1].

Key Findings

  • Pooled LDL reduction was 0.33 mmol/L (95% CI: 0.27–0.38 mmol/L lower).
  • Non-HDL cholesterol fell by 0.39 mmol/L (95% CI: 0.27–0.50 mmol/L lower).
  • Apolipoprotein B fell by 0.05 g/L (95% CI: 0.03–0.08 g/L lower).
  • The review graded LDL and non-HDL evidence moderate because results varied across studies; apoB evidence was high.
  • Included trials lasted at least three weeks. The median studied dose does not establish one optimal regimen.

Study Details

Effect of psyllium (Plantago ovata) fiber on LDL cholesterol and alternative lipid targets: a systematic review and meta-analysis of randomized controlled trials
Jovanovski E, Yashpal S, Engkaninan A, Gijón-Conde T, Gómez-Juaristi M, et al. — American Journal of Clinical Nutrition (2018)
Psyllium fiber at a median dose of 10.2g/day reduced LDL cholesterol by 0.33 mmol/L
1,924 participantsModerate

Practical Takeaway

Psyllium may complement a clinician-guided cholesterol plan. Follow product-specific instructions, take it with adequate liquid, and discuss medication timing with a pharmacist. It does not replace prescribed treatment [1,3].

Summary

A comprehensive meta-analysis evaluating the LDL cholesterol-lowering effects of psyllium husk fiber supplementation across 28 randomized controlled trials in adults with mild to moderate hypercholesterolemia.

Related Supplements

Psyllium Husk

Related Conditions

Gut Health & DigestionBlood Sugar ManagementBlood PressureIrritable Bowel Syndrome (IBS)

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Frequently Asked Questions

How much does psyllium lower cholesterol?

The pooled LDL reduction was about 13 mg/dL. A percentage change depends on the starting LDL level, and the average does not predict an individual response [1].

Evidence:Study (2018)[#1]. See full reference list below.

How long does psyllium take to lower cholesterol?

The review included studies lasting at least three weeks. It does not establish an exact onset or maximum effect at six to eight weeks for everyone. Agree on follow-up testing with the clinician managing your cholesterol [1].

Evidence:Study (2018)[#1]. See full reference list below.

Can I take psyllium with cholesterol medication?

Psyllium can affect absorption of some medicines. Ask a pharmacist about the appropriate interval for each medicine rather than applying a universal two-hour-before/four-hour-after statin rule. Do not change or stop prescribed cholesterol treatment on your own [3].

Evidence:Study (2024)[#3]. See full reference list below.

What is the best way to take psyllium for cholesterol?

Follow the label for the specific formulation. MedlinePlus instructs users to take psyllium with at least 8 ounces (240 mL) of liquid; powder or granules should be mixed immediately before use. Ask for medical advice first if you have swallowing difficulty or a history of intestinal blockage [3].

Evidence:Study (2024)[#3]. See full reference list below.

Does psyllium help with triglycerides?

This review focused on LDL, non-HDL cholesterol, and apolipoprotein B. Those findings do not establish a triglyceride-treatment recommendation. Discuss elevated triglycerides with a clinician rather than substituting another supplement [1].

Evidence:Study (2018)[#1]. See full reference list below.

Continue Reading

Supplement Guide

Psyllium Husk

Psyllium can support bowel regularity and modestly lower LDL cholesterol. Start gradually, follow the product dose, and take each serving with at least 240 mL of liquid. [11][14]

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Condition Guide

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References

  1. Jovanovski E, Yashpal S, Engkaninan A, Gijón-Conde T, Gómez-Juaristi M, et al. (2018). Effect of psyllium (Plantago ovata) fiber on LDL cholesterol and alternative lipid targets: a systematic review and meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition. DOI PubMed
  2. Wei ZH, Wang H, Chen XY, Wang BS, Rong ZX, Wang BS, et al. (2019). Time- and dose-dependent impact of psyllium on gut microbiota and short-chain fatty acids in the context of hyperlipidemia. Lipids in Health and Disease.

    Citation identity under review. The listed publication identity could not be verified from the primary records reviewed. An unrelated or unresolvable identifier has been removed; this entry should not be used as verified support for a health claim.

  3. MedlinePlus (2024). Psyllium: Drug Information. U.S. National Library of Medicine.