General Dosage
100 million to 10 billion cells daily
Maximum dose: No established upper limit; clinical trials have used up to 10 billion cells/day safely
Akkermansia Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 100 million to 10 billion cells daily
Timing: With or without food; morning dosing most common in clinical trials
Dosage by Condition
Metabolic health
10 billion cells daily (pasteurized)Emerging
Gut barrier support
100 million to 1 billion cells dailyEmerging
General gut health
100 million cells dailyPreliminary
| Condition | Recommended Dose | Evidence |
|---|---|---|
| Metabolic health | 10 billion cells daily (pasteurized) | Emerging |
| Gut barrier support | 100 million to 1 billion cells daily | Emerging |
| General gut health | 100 million cells daily | Preliminary |
Upper limit: No established upper limit; clinical trials have used up to 10 billion cells/day safely
Timing & Absorption
With or without food; morning dosing most common in clinical trials
Can be taken with or without food.
References
- Depommier C, Everard A, Druart C, et al. (2019). Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature Medicine. DOI PubMed
- Plovier H, Everard A, Druart C, et al. (2017). A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium improves metabolism in obese and diabetic mice. Nature Medicine. DOI PubMed
- Cani PD, de Vos WM (2017). Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila. Frontiers in Microbiology. DOI PubMed