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Akkermansia Dosage Guide

Evidence:Emerging
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

General Dosage

100 million to 10 billion cells daily

Maximum dose: No established upper limit; clinical trials have used up to 10 billion cells/day safely

Dosage Recommendations

General recommendation: 100 million to 10 billion cells daily

Timing: With or without food; morning dosing most common in clinical trials

Dosage by Condition

Metabolic health
10 billion cells daily (pasteurized)Emerging
Gut barrier support
100 million to 1 billion cells dailyEmerging
General gut health
100 million cells dailyPreliminary

Upper limit: No established upper limit; clinical trials have used up to 10 billion cells/day safely

Timing & Absorption

With or without food; morning dosing most common in clinical trials

Can be taken with or without food.

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References

  1. RCTDepommier C, Everard A, Druart C, et al. (2019). Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature Medicine. DOI PubMed
  2. ReviewCani PD, de Vos WM (2017). Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila. Frontiers in Microbiology. DOI PubMed
  3. RCTZhang Y, Liu R, Chen Y, Cao Z, et al. (2025). Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut.. Cell metabolism. DOI PubMed
  4. Mörkl S, Narrath M, Schlotmann D, Sallmutter MT, et al. (2025). Multi-species probiotic supplement enhances vagal nerve function - results of a randomized controlled trial in patients with depression and healthy controls.. Gut microbes. DOI PubMed
  5. Climent E, Hevilla F, Padial M, Barril-Cuadrado G, et al. (2025). Psychobiotic Protection of Nutritional Supplements and Probiotics in Patients Undergoing Hemodialysis: A Randomized Trial.. Nutrients. DOI PubMed
  6. Tsai YS, Lin XB, Lin SW, Chen YL, et al. (2025). Impact of probiotic Lactobacillus plantarum GKM3 on gastrointestinal health in overweight and obese individuals: A randomized clinical trial.. Clinical nutrition ESPEN. DOI PubMed
  7. Tana C, Moffa S, Tana M, Ucciferri C, et al. (2025). Gut Microbiota, Mild Cognitive Impairment and Dementia: A Systematic Review.. Neurology international. DOI PubMed
Show 3 more references
  1. RCTKang CH, Jung ES, Jung SJ, Han YH, et al. (2024). Pasteurized Akkermansia muciniphila HB05 (HB05P) Improves Muscle Strength and Function: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.. Nutrients. DOI PubMed
  2. Jardon KM, Goossens GH, Most J, Galazzo G, et al. (2024). Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity.. Gut microbes. DOI PubMed
  3. Calvani R, Giampaoli O, Marini F, Del Chierico F, et al. (2024). Beetroot juice intake positively influenced gut microbiota and inflammation but failed to improve functional outcomes in adults with long COVID: A pilot randomized controlled trial.. Clinical nutrition (Edinburgh, Scotland). DOI PubMed