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Akkermansia Side Effects & Safety

Evidence:Emerging
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Mild bloating or gas during the first week of supplementation (common with any probiotic)
  • Rare: changes in stool consistency as microbiome adapts
  • No serious adverse events reported in clinical trials to date

Drug & Supplement Interactions

  • Metformin — Akkermansia levels naturally increase with metformin use; combined supplementation may have additive metabolic effects (consult physician)
  • Immunosuppressants — as with all probiotics, those on immunosuppressive therapy should consult a doctor before use
  • Antibiotics — broad-spectrum antibiotics will reduce or eliminate supplemented Akkermansia colonies

Maximum Dose

Do not exceed: No established upper limit; clinical trials have used up to 10 billion cells/day safely

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References

  1. RCTDepommier C, Everard A, Druart C, et al. (2019). Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature Medicine. DOI PubMed
  2. ReviewCani PD, de Vos WM (2017). Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila. Frontiers in Microbiology. DOI PubMed
  3. RCTZhang Y, Liu R, Chen Y, Cao Z, et al. (2025). Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut.. Cell metabolism. DOI PubMed
  4. Mörkl S, Narrath M, Schlotmann D, Sallmutter MT, et al. (2025). Multi-species probiotic supplement enhances vagal nerve function - results of a randomized controlled trial in patients with depression and healthy controls.. Gut microbes. DOI PubMed
  5. Climent E, Hevilla F, Padial M, Barril-Cuadrado G, et al. (2025). Psychobiotic Protection of Nutritional Supplements and Probiotics in Patients Undergoing Hemodialysis: A Randomized Trial.. Nutrients. DOI PubMed
  6. Tsai YS, Lin XB, Lin SW, Chen YL, et al. (2025). Impact of probiotic Lactobacillus plantarum GKM3 on gastrointestinal health in overweight and obese individuals: A randomized clinical trial.. Clinical nutrition ESPEN. DOI PubMed
  7. Tana C, Moffa S, Tana M, Ucciferri C, et al. (2025). Gut Microbiota, Mild Cognitive Impairment and Dementia: A Systematic Review.. Neurology international. DOI PubMed
Show 3 more references
  1. RCTKang CH, Jung ES, Jung SJ, Han YH, et al. (2024). Pasteurized Akkermansia muciniphila HB05 (HB05P) Improves Muscle Strength and Function: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.. Nutrients. DOI PubMed
  2. Jardon KM, Goossens GH, Most J, Galazzo G, et al. (2024). Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity.. Gut microbes. DOI PubMed
  3. Calvani R, Giampaoli O, Marini F, Del Chierico F, et al. (2024). Beetroot juice intake positively influenced gut microbiota and inflammation but failed to improve functional outcomes in adults with long COVID: A pilot randomized controlled trial.. Clinical nutrition (Edinburgh, Scotland). DOI PubMed