General Dosage
300-600mg daily on an empty stomach
Maximum dose: 1200mg/day (doses used in clinical trials; higher doses may cause GI issues)
Alpha-Lipoic Acid Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 300-600mg daily on an empty stomach
Timing: On an empty stomach 30 minutes before meals for best absorption; split into 2 doses if using 600mg+
Dosage by Condition
General antioxidant / longevity
300mg dailyModerate
Diabetic neuropathy
600mg dailyStrong
Blood sugar support
300-600mg dailyModerate
| Condition | Recommended Dose | Evidence |
|---|---|---|
| General antioxidant / longevity | 300mg daily | Moderate |
| Diabetic neuropathy | 600mg daily | Strong |
| Blood sugar support | 300-600mg daily | Moderate |
Upper limit: 1200mg/day (doses used in clinical trials; higher doses may cause GI issues)
Timing & Absorption
On an empty stomach 30 minutes before meals for best absorption; split into 2 doses if using 600mg+
Can be taken with or without food.
References
- Ziegler D, Ametov A, Barinov A, et al. (2006). Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes Care. DOI PubMed
- Ansar H, Mazloom Z, Kazemi F, Hejazi N (2011). Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients. Saudi Medical Journal. PubMed
- Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM (2009). Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochimica et Biophysica Acta. DOI PubMed