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Apigenin — Frequently Asked Questions

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Frequently Asked Questions

Is apigenin the same as chamomile?

No — apigenin is a single flavonoid compound found in chamomile, but chamomile contains many other active compounds including other flavonoids, terpenoids, and coumarins. Taking purified apigenin gives you the primary sleep-promoting compound in a standardized dose, while chamomile extract provides the full spectrum of chamomile compounds. Both approaches are valid; apigenin offers precision, while chamomile extract may benefit from synergistic effects.

Does apigenin really boost NAD+ levels?

In cell and animal studies, yes — Escande et al. (2013) showed apigenin inhibits CD38, the primary NAD+-consuming enzyme in mammalian cells, resulting in increased intracellular NAD+ levels. However, this effect has not been confirmed in human clinical trials at typical supplement doses (50mg). The NAD+ benefit should be considered a promising secondary effect rather than the primary reason to take apigenin.

Is 50mg of apigenin enough for sleep?

The 50mg dose is widely used based on extrapolation from chamomile clinical trials and was popularized by neuroscientist Andrew Huberman. Many users report subjective sleep improvement at this dose. However, no direct dose-ranging study of purified apigenin for sleep has been published. Some people may benefit from higher doses (up to 100mg), but caution is warranted given limited human dosing data. Start with 50mg and assess your response before increasing.

Full Apigenin Guide

References

  1. (). Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochemical Pharmacology. DOI
  2. (). Flavonoid apigenin is an inhibitor of the NAD+ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome. Diabetes. DOI
  3. (). A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. Journal of Clinical Psychopharmacology. DOI