Safety Profile
Overall safety rating: Generally Safe
Boron Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Generally very well-tolerated at 3-10mg daily
- Nausea and diarrhea (uncommon, usually at higher doses)
- Upper GI discomfort (rare)
- Toxicity with massive doses (>100mg) — vomiting, diarrhea, skin rash
Drug & Supplement Interactions
- May enhance the effects of estrogen therapy — use caution with HRT
- May interact with medications metabolized by the liver
- Enhances magnesium and calcium retention — beneficial synergy with these supplements
Maximum Dose
Do not exceed: 20mg/day (NIH UL); doses up to 10mg daily are well-tolerated in studies
References
- Naghii MR, Mofid M, Asgari AR, Hedayati M, Daneshpour MS (2011). Comparative effects of daily and weekly boron supplementation on plasma steroid hormones and proinflammatory cytokines. Journal of Trace Elements in Medicine and Biology. DOI PubMed
- Pietrzkowski Z, Phelan MJ, Keller R, Shu C, Argumedo R, Reyes-Izquierdo T (2014). Short-term efficacy of calcium fructoborate on subjects with knee discomfort: a comparative, double-blind, placebo-controlled clinical study. Clinical Interventions in Aging. DOI PubMed
- Nielsen FH, Hunt CD, Mullen LM, Hunt JR (1987). Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB Journal. DOI PubMed