Safety Profile
Overall safety rating: Generally Safe
DGL Licorice Side Effects & Safety
Evidence:Moderate
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Potential Side Effects
- Very well tolerated — glycyrrhizin removal eliminates the main licorice safety concerns
- Mild nausea in some individuals
- Extremely rare allergic reactions
Drug & Supplement Interactions
- Regular licorice/glycyrrhizin-containing products — do not combine; DGL is safe but regular licorice causes hypertension
- Warfarin — licorice flavonoids may have mild antiplatelet activity
- Generally very few drug interactions due to glycyrrhizin removal
Maximum Dose
Do not exceed: 2,280mg DGL per day (760mg 3x daily)
References
- Morgan AG, McAdam WA, Pacsoo C, et al. (1985). Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy. Gut. DOI PubMed
- Raveendra KR, Jayachandra, Srinivasa V, et al. (2012). An extract of Glycyrrhiza glabra (GutGard) alleviates symptoms of functional dyspepsia: a randomized, double-blind, placebo-controlled study. Evidence-Based Complementary and Alternative Medicine. DOI PubMed