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Digestive Enzymes Research & Evidence

This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer

Evidence Level

Moderate

Digestive enzymes have a clear role in pancreatic exocrine insufficiency, where PERT is standard of care. For targeted food intolerances (lactase for lactose, alpha-galactosidase for legume sugars), single-enzyme products are well-supported. The evidence for OTC broad-spectrum enzymes in functional dyspepsia is emerging but growing. A key limitation is that many OTC products do not undergo the same rigorous testing as prescription PERT products.

Evidence by Condition

ConditionStudied DoseEvidence
Pancreatic insufficiency (EPI)25,000-75,000 USP units lipase per meal (Rx)Strong
Lactose intolerance3,000-9,000 FCC units lactase with dairyStrong
General bloating/dyspepsiaBroad-spectrum enzyme with each mealEmerging
Full Digestive Enzymes Guide

References

  1. (). Pancreatic enzyme replacement therapy: exocrine pancreatic insufficiency after gastrointestinal surgery. HPB. DOI
  2. (). A multi-enzyme preparation reduces bloating and gas-related symptoms in a double-blind randomized controlled trial. Clinical and Translational Gastroenterology. DOI