Safety Profile
Overall safety rating: Generally Safe
Eggshell Membrane (NEM) Side Effects & Safety
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Potential Side Effects
- Generally very well tolerated
- Mild GI discomfort (uncommon)
- Contraindicated in individuals with egg allergy
- Mild headache (rare)
Drug & Supplement Interactions
- No significant drug interactions reported
- Safe to combine with other joint supplements (glucosamine, chondroitin, etc.)
- Contraindicated for individuals with egg allergy
Maximum Dose
Do not exceed: 500mg daily is the studied dose; no evidence for additional benefit at higher doses
References
- Ruff KJ, Winkler A, Jackson RW, et al. (2009). Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study. Clinical Rheumatology. DOI PubMed
- Ruff KJ, Morrison D, Duncan SA, et al. (2018). Beneficial effects of natural eggshell membrane versus placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women. Clinical Interventions in Aging. DOI PubMed
- Brunello E, Masini A (2016). Natural eggshell membrane (NEM) clinical studies: a comprehensive review. Agro Food Industry Hi-Tech.