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Eggshell Membrane (NEM) Side Effects & Safety

Evidence:Moderate
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This content is for informational purposes only and does not constitute medical advice. Statements about dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary — consult your healthcare provider before starting any supplement. Full disclaimer

Safety Profile

Overall safety rating: Generally Safe

Potential Side Effects

  • Generally very well tolerated
  • Mild GI discomfort (uncommon)
  • Contraindicated in individuals with egg allergy
  • Mild headache (rare)

Drug & Supplement Interactions

  • No significant drug interactions reported
  • Safe to combine with other joint supplements (glucosamine, chondroitin, etc.)
  • Contraindicated for individuals with egg allergy

Maximum Dose

Do not exceed: 500mg daily is the studied dose; no evidence for additional benefit at higher doses

Full Eggshell Membrane (NEM) Guide

References

  1. RCTRuff KJ, Winkler A, Jackson RW, et al. (2009). Eggshell membrane in the treatment of pain and stiffness from osteoarthritis of the knee: a randomized, multicenter, double-blind, placebo-controlled clinical study. Clinical Rheumatology. DOI PubMed
  2. RCTRuff KJ, Morrison D, Duncan SA, et al. (2018). Beneficial effects of natural eggshell membrane versus placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women. Clinical Interventions in Aging. DOI PubMed
  3. ReviewBrunello E, Masini A (2016). Natural eggshell membrane (NEM) clinical studies: a comprehensive review. Agro Food Industry Hi-Tech.