General Dosage
100-300mg standardized GSE (95% OPCs) daily
Maximum dose: 600mg/day (well-tolerated in clinical trials)
Grape Seed Extract Dosage Guide
This content is for informational purposes only and does not constitute medical advice. Consult your healthcare provider before starting any supplement. Full disclaimer
Dosage Recommendations
General recommendation: 100-300mg standardized GSE (95% OPCs) daily
Timing: Can be taken any time of day; divide into 2 doses for sustained antioxidant coverage • Take with food for best absorption.
Dosage by Condition
High blood pressure
150-300mg GSE dailyModerate
Chronic venous insufficiency
150-300mg GSE dailyModerate
Antioxidant support
100-200mg GSE dailyModerate
Endothelial function
200-400mg GSE dailyEmerging
| Condition | Recommended Dose | Evidence |
|---|---|---|
| High blood pressure | 150-300mg GSE daily | Moderate |
| Chronic venous insufficiency | 150-300mg GSE daily | Moderate |
| Antioxidant support | 100-200mg GSE daily | Moderate |
| Endothelial function | 200-400mg GSE daily | Emerging |
Upper limit: 600mg/day (well-tolerated in clinical trials)
Timing & Absorption
Can be taken any time of day; divide into 2 doses for sustained antioxidant coverage
Best taken with food for optimal absorption.
References
- Zhang H, Liu S, Li L, Liu S, Liu S, Mi J, Tian G (2016). The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials. Medicine. DOI PubMed
- Feringa HH, Laskey DA, Dickson JE, Coleman CI (2011). The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials. Journal of the American Dietetic Association. DOI PubMed